CAS 248282-01-1; paquinimod

CAS:

248282-01-1

分子式:

C₂₁H₂₂N₂O₃

分子量:

350.41

英文名称:

paquinimod

abr-25757

abr215757

abr 215757

abr25757

abr 25757

n-ethyl-n-phenyl-1,2-dihydro-5-ethyl-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide

abr-215757

n,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-n-phenyl-3-quinolinecarboxamide

n-ethyl-n-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide

用途:

Paquinimod 是一种 S100A9 抑制剂，阻止 S100A9 与 TLR-4 结合。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

P880045

MACKLIN

Paquinimod

≥98%

378元/5mg; 599元/10mg; 1001元/25mg; 2560元/100mg; 4351元/250mg;

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储存：2-8℃
状态：白色到灰白色固体

SML2883

Sigma-Aldrich

Paquinimod

≥98% (HPLC)

1042.98元/5 MG; 4208.37元/25 MG;

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产品说明

生化/生理作用

Paquinimod (ABR-215757) is an orally active quinoline-3-carboxamide (Q substance) class immunomodulator that targets S100A9 (Calgranulin B; MRP14) via direct binding and blocks its interaction with receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (IC₅₀ = 26 μM & 23 μM against 100 nM hS100A9 from binding immobilized hRAGE & hTLR4/MD2, respectively). Paquinimod in vivo efficacy is demonstrated in murine models of autoimmune/inflammatory diseases, including liver fibrosis, collagen-induced osteoarthritis, peritonitis, EAE, type 1 diabetes, lupus (0.04-25 mg/kg/day p.o.), and atherosclerosis (10 mg/kg i.p.).

基本信息

经验(实验)分子式	C₂₁H₂₂N₂O₃
分子量	350.41
MDL编号	MFCD18633277

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable