CAS 2457-80-9; 5'-s-methylthioadenosine

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货号

品牌

产品名称

规格

包装、参考价格

Y19802

Alfa Aesar

5'-Methylthioadenosine

1758元/100mg; 2821元/250mg; 6809元/1g;

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基本信息

分子量
297.33

D5011

Sigma-Aldrich

5′-Deoxy-5′-(methylthio)adenosine

827.39元/25 MG; 2438.2元/100 MG; 4166.25元/250 MG; 12838元/1 G;

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产品说明

应用

5′-脱氧-5′-(甲硫基)腺苷已被用作蛋白质甲基化抑制剂，可降低肝细胞癌(HCC)细胞中的E2F转录因子1(E2F1)蛋白丰度。这种成分还用于抑制组蛋白甲基化修饰，研究其在缺氧诱导因子1(Hif-1)核转运中的作用。

包装

1 g in poly bottle
25, 100, 250 mg in poly bottle

生化/生理作用

5′-脱氧-5′-(甲硫基)腺苷(甲硫腺苷)可用作底物来研究5′-甲硫腺苷磷酸化酶(MTAP)(EC2.4.2.28)的特异性和动力学，该酶是一个肿瘤抑制基因所表达的酶，其可支持S-腺苷甲硫氨酸(AdoMet)和蛋氨酸补救途径。

其他说明

Scripps Center for Metabolomics(斯克里普斯代谢组学中心)独立生成的串联质谱数据，可以PDF格式查看或下载。 D5011.pdf 经过测试的代谢物在Scripps Center for Metabolomics(斯克里普斯代谢组学中心) METLIN 代谢物数据库中有重点介绍。更多信息请见sigma.com/metlin。

基本信息

经验(实验)分子式	C₁₁H₁₅N₅O₃S
分子量	297.33
Beilstein	42420
MDL编号	MFCD00010533
PubChem化学物质编号	24893915
NACRES	NA.51

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥98% (HPLC)
形式	powder
溶解性	DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
储存温度	−20℃
SMILES string	CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI	1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key	WUUGFSXJNOTRMR-IOSLPCCCSA-N
Gene Information	human ... ADORA2B(136), ADORA3(140) mouse ... Mtap(66902) rat ... Adora1(29290), Adora2a(25369)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

260585

Sigma-Aldrich

5'-Deoxy-5'-methylthioadenosine-CAS 2457-80-9-Calbiochem

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP).

1836.91元/50 MG;

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产品说明

一般描述

A cell-permeable, reversible, and ATP-competitive naturally-occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). Potently inhibits the protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also inhibits FGF-2 receptor tyrosine kinase activity as well as the proliferation of human astrocytes and glioma cells.
A naturally occurring co-product of polyamine biosynthesis that acts as an endogenous substrate of methylthioadenosine phosphorylase (MTAP). A cell-permeable, reversible, and ATP-competitive inhibitor of protein carboxymethyltransferase and induces apoptosis in leukemia U937 cells. Also acts as an inhibitor of NGF-induced tyrosine phosphorylation in PC12 cells and blocks FGF-2 receptor tyrosine kinase in astrocytes and glioma cells.

包装

50 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
protein carboxymethyltranferase
Secondary Target
FGF-2receptor tyrosine kinase activity

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.

其他说明

Lee, S.H., and Cho, Y.D. 1998. Exp. Cell Res.240, 282.
Smalheiser, N.R. 1998. Brain Res. Dev. Brain Res.51, 53.
Joy, A., et al. 1997. Oncogene14, 171.
Riscoe, M.K., et al. 1984. Biochem. Pharmacol.33, 3639.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₁H₁₅N₅O₃S
分子量	297.33

产品性质

质量水平	100
测定	≥99% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	white
溶解性	DMF: 25 mg/mL DMSO: soluble
运输	ambient
储存温度	−20℃
InChI	1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)
InChI key	WUUGFSXJNOTRMR-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

230436

Fluorochem

(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

95%

3674元/250mg; 9372元/1g;

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基本信息

CAS Number	2457-80-9
MDL Number	MFCD00010533

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.