CAS 244240-24-2; α-cyano-β-hydroxy-β-methyl-n-(2,5-dibromophenyl)propenamide; lfm-a13

CAS:

244240-24-2

分子式:

C₁₁H₈Br₂N₂O₂

分子量:

360

中文名称:

α-cyano-β-hydroxy-β-methyl-n-(2,5-dibromophenyl)propenamide

英文名称:

lfm-a13

(2z)-2-cyano-n-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-cyano-b-hydroxy-b-methyl-n-(2,5-dibromophenyl)propenamide

用途:

LFM-A13是一种特异性布鲁顿氏酪氨酸激酶(BTK)抑制剂，IC50为2.5 μM,选择性比其他蛋白激酶，包括JAK1，JAK2，HCK，EGFR，和 IRK高100多倍。在BTK+ B系白血病细胞中，LFM-A13增强它们对神经酰胺或长春新碱诱导的细胞凋亡的敏感性。[1]在BCL-1细胞，NALM-6细胞，或正常BALB/c脾细胞，LFM-13抑制BCL-1细胞中BTK的酶活性，而不影响BTK蛋白表达水平。[2]在人嗜中性粒细胞中，LFM-A13降低fMet-Leu-Phe诱导的酪氨酸磷酸化，并抑制超氧阴离子的产生和粘附，趋化的刺激，以及磷脂酶D活性。[3]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

L792311

MACKLIN

LFM-A13

10mM in DMSO

251元/1ml;

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储存：-20°C

L872510

MACKLIN

LFM-A13

99%

479元/5mg; 1400元/25mg;

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储存：-20℃
状态：粉末

L6920

Sigma-Aldrich

LFM-A13

≥98% (HPLC), powder

1202.81元/5 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₁H₈Br₂N₂O₂
分子量	360.00
MDL编号	MFCD09878279
PubChem化学物质编号	329817646
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: ≥19 mg/mL
储存温度	2-8℃
SMILES string	C\C(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br
InChI	1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-
InChI key	UVSVTDVJQAJIFG-VURMDHGXSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H312 + H332
预防措施声明	P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable