CAS 24424-99-5; 二叔丁基焦碳酸酯; Di-tert-butyl dicarbonate solution

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基本信息

货号

品牌

产品名称

规格

包装、参考价格

767416

MACKLIN

二碳酸二叔丁酯溶液

1.0 M in THF

499元/100ml;

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储存：2-8°C
状态：液体

D806925

MACKLIN

二碳酸二叔丁酯

99%

47元/25g; 116元/100g; 570元/1kg; 2650元/5kg;

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储存：2~8°C
状态：白色固体或无色液体
折射率：n20/D 1.409(lit.)

D806924

MACKLIN

二碳酸二叔丁酯

98%

30元/25g; 51元/100g; 161元/500g; 658元/2.5kg; 1069元/5kg; 1999元/10kg;

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储存：2~8°C
状态：白色低熔点晶体固体或液体
折射率：n20/D 1.409(lit.)

D1547

TCI

Di-tert-butyl Dicarbonate [Boc-reagent for Amino Acid]

>95.0%(T)

105元/25G; 195元/100G; 565元/500G;

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基本信息

纯度/分析方法	>95.0%(T)
分子式/分子量	C₁₀H₁₈O₅ = 218.25
外观与形状(20℃)	固体
储存温度	0-10℃
储存在惰性气体下	存放于惰性气体之中
应避免的情况	湿气 (分解),加热
Reaxys-RN	1911173
PubChem物质ID	87568033
SDBS (AIST Spectral DB)	22556
MDL编号	MFCD00008805

技术规格

Appearance	White or Colorless to Light yellow powder to lump to clear liquid
Purity(Morpholine Method)	min. 95.0 %

物性(参考值)

熔点	23 ℃
闪点	47 ℃
水溶性	实际上不溶
溶解性(易溶于)	甲苯,丙酮

安全信息

图形或危害标志
信号词	危险
危险性说明	H330 : 吸入致命。 H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。 H228 : 易燃固体。
防范说明	P501 : 将内装物/容器送到批准的废物处理厂处理。 P260 : 不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸气/ 喷雾。 P240 : 容器和装载设备接地/等势联接。 P210 : 远离热源/火花/明火/热表面。禁止吸烟。 P241 : 使用防爆的电气/通风/照明设备。 P271 : 只能在室外或通风良好之处使用。 P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P284 : [在通风不足的情况下]戴呼吸防护装置。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P370 + P378 : 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 P304 + P340 + P310 : 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。立即呼叫急救中心/医生。 P403 + P233 : 存放在通风良好的地方。保持容器密闭。 P405 : 存放处须加锁。

相关法规

RTECS#

HT0230000

运输信息

UN编号	UN2930
类别	6.1 / 4.1
包装类别	II
监管条件代码(*)

317468

J&K

Di-tert-butyl dicarbonate

95%

68元/25G; 141元/100G; 419元/500G;

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基本信息

分子式	C₁₀H₁₈O₅
分子量	218.25
熔点	23
沸点	56-57
闪点	37
密度	0.95
折光率(n20D)	1.4090
MDL编码	MFCD00008805
Beilstein	1911173
EINECS 编号	246-240-1
存储条件	Store at 2-8℃

安全信息

图形或危害标志
提示语	Danger
危险说明	H226 H315 H317 H318 H330 H335
防范说明	P210 P260 P280 P304+P340+P310 P305+P351+P338 P370+P378
UN号码	2929
危险分类	6.1
次要危险性	3
包装等级	II
WGK	3
RTECS	HT0230000
TSCA	是

252225

J&K

Di-tert-butyl dicarbonate

99%

140元/25G; 410元/100G; 1427元/500G;

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基本信息

分子式	C₁₀H₁₈O₅
分子量	218.25
熔点	22-26
沸点	56-57
闪点	37
密度	0.95
折光率(n20D)	1.4090
MDL编码	MFCD00008805
Beilstein	1911173
EINECS 编号	246-240-1
存储条件	Store at 2-8℃

安全信息

图形或危害标志
提示语	Danger
危险说明	H226 H315 H317 H319 H330 H335
防范说明	P260 P280 P284 P305+P351+P338 P310
UN号码	2929
危险分类	6.1
次要危险性	3
包装等级	I
WGK	3
RTECS	HT0230000
TSCA	是

A14708

Alfa Aesar

Di-tert-butyl dicarbonate

97+%

662元/25g; 1809元/100g; 8204元/500g;

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应用
Reagent for the introduction of the Boc protecting group.Di-tert-butyl dicarbonate is a reagent used for the introduction of BOC protecting group. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.

备注
Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Moisture and light sensitive. Incompatible with oxidizing agents, reducing agents, bases and acids.

基本信息

MDL
MFCD00008805

EINECS
246-240-1

分子式
C₁₀H₁₈O₅

分子量
218.25

熔点
21-24°

沸点
56-57°/0.5mm

闪点
37°(99°F)

密度
0.950

折射率
1.4090

灵敏度
Keep Cold. Moisture Sensitive. Store under Nitrogen.

形态
Low melting solid

溶解性
Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.

Beilstein
1911173

GHS危害和防范说明

GHS符号

Hazard Statements
H228-H330-H315-H318-H317-H335
Flammable solid.Fatal if inhaled.Causes skin irritation.Causes serious eye damage.May cause an allergic skin reaction.May cause respiratory irritation.

Precautionary Statements
P280-P305+P351+P338-P304+P340-P310a-P302+P352a
Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.

安全信息

危险等级
6.1

包装组
II

危险类别
11-26-37/38-41-43
Highly flammable.Very toxic by inhalation.Irritating to respiratory system and skin.Risk of serious damage to eyes.May cause sensitization by skin contact.

安全等级
9-26-28-36/37/39-45-60
Keep container in a well-ventilated place.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
HT0230000

TSCA
是

34660

Sigma-Aldrich

Di-tert-butyl dicarbonate

≥98.0% (GC)

231.65元/25 G; 880.27元/100 G; 1583.41元/500 G;

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产品说明

一般描述

二-叔-二碳酸丁酯(Boc₂O)作为试剂，主要用于将 Boc 保护基团引入胺官能团。在某些有机反应，尤其是与羧酸、某些羟基或与伯硝基烷烃反应中，它也用作脱水剂。

应用

二-叔-二碳酸丁酯(Boc₂O)用于：

合成偶氮苯氨基酸(aa)。
从MDMA合成 N-叔丁基羰基-3,4-亚甲基二氧甲基苯丙胺 (t-BOC-MDMA) 。

也可以用作试剂，用于：

在氨基酸、多肽和蛋白质中引入对酸不稳定的Boc保护基
在 Pd 作为催化剂的条件下，通过芳族羧酸的 Heck 烯化反应制备苯乙烯衍生物
以 DMAP 为催化剂，通过1,2-氨基醇和1,2-二胺的异氰酸酯化反应合成恶唑烷-2-酮和咪唑啉-2-酮
从 MDMA 制备 N-叔丁基羰基-3,4-亚甲基二氧甲基苯丙胺 (t-Boc-MDMA)
将胺转化为相应异氰酸酯、氨基甲酸酯和尿素衍生物
酰胺 N-BOC-化
非水条件下敏感化合物 N-BOC-化。

用于引入叔丁氧羰基保护基团的试剂。

包装

25, 100, 500 g in poly bottle

警告

水解为叔丁醇和 CO₂；暴露在潮湿环境中会导致瓶内压力增大。

基本信息

线性分子式	[(CH₃)₃COCO]₂O
分子量	218.25
Beilstein	1911173
EC 号	246-240-1
MDL编号	MFCD00008805
PubChem化学物质编号	329755051
NACRES	NA.22

产品性质

质量水平	200
测定	≥98.0% (GC)
折射率	n20/D 1.409 (lit.)
bp	56-57 ℃/0.5 mmHg (lit.)
mp	23 ℃ (lit.)
密度	0.95 g/mL at 25 ℃ (lit.)
application(s)	peptide synthesis
储存温度	2-8℃
SMILES string	CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
InChI	1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
InChI key	DYHSDKLCOJIUFX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H226 - H315 - H317 - H318 - H330 - H335
预防措施声明	P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	3 - Flammable liquids
WGK	WGK 3
闪点(F)	98.6 °F - closed cup
闪点(C)	37 ℃ - closed cup
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

436267

Sigma-Aldrich

Di-tert-butyl dicarbonate solution

1.0 M in THF

410.83元/100 ML; 1579.24元/800 ML;

咨询

基本信息

线性分子式	O[CO₂C(CH₃)₃]₂
分子量	218.25
MDL编号	MFCD00008805
PubChem化学物质编号	24867291
NACRES	NA.22

产品性质

质量水平	200
浓度	1.0 M in THF
bp	65-67 ℃
密度	0.913 g/mL at 25 ℃
application(s)	peptide synthesis
SMILES string	CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
InChI	1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
InChI key	DYHSDKLCOJIUFX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H225 - H315 - H317 - H318 - H330 - H335 - H336 - H351
预防措施声明	P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 1 Inhalation - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - Skin Sens. 1
补充剂危害	EUH019
储存分类代码	3 - Flammable liquids
WGK	WGK 3
闪点(F)	1.4 °F - closed cup
闪点(C)	-17 ℃ - closed cup
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

8.18282

Sigma-Aldrich

Di-tert-butyl dicarbonate

for synthesis

221.91元/25 ML; 324.26元/100 ML; 837.26元/500 ML;

咨询

产品说明

一般描述

for synthesis

应用

Di-tert-butyl dicarbonate for synthesis. CAS 24424-99-5, molar mass 218.25 g/mol.

分析说明

Assay (GC, area%)

≥ 98.0 % (a/a)

Melting range (lower value)

≥ 20 °C

Melting range (upper value)

≤ 24 °C

Identity (IR)

passes test

Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

分子量	218.25
MDL编号	MFCD00008805
EC索引号	246-240-1

产品性质

质量水平	200
自燃温度	460 ℃
效能	>5000 mg/kg LD₅₀, oral (Rat) >2000 mg/kg LD₅₀, skin (Rabbit)
bp	56-57 ℃/0.7 hPa
mp	20-24 ℃
转变温度	flash point 37 ℃
密度	1.02 g/cm³ at 20 ℃
储存温度	2-8℃
InChI	1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
InChI key	DYHSDKLCOJIUFX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H226 - H315 - H317 - H318 - H330 - H335
预防措施声明	P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 2 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官	Respiratory system
储存分类代码	3 - Flammable liquids
WGK	WGK 3
闪点(F)	98.6 °F - closed cup
闪点(C)	37 ℃ - closed cup

CAS Number	24424-99-5
MDL Number	MFCD00008805
Boiling Point	56-57℃
Melting Point	21-24℃
Density	0.95

CAS Number	24424-99-5
MDL Number	MFCD00008805
Boiling Point	56 - 57 ℃
Density	0.934

形式	liquid
质量水平	100
浓度	2 M in methylene chloride
密度	1.162 g/mL at 25 ℃
SMILES string	CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
InChI	1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
InChI key	DYHSDKLCOJIUFX-UHFFFAOYSA-N

图形或危害标志
危险性说明	H228: Flammable solid. H315: Causes skin irritation. H317: May cause an allergic skin reaction. H318: Causes serious eye damage. H330: Fatal if inhaled. H335: May cause respiratory irritation.
防范说明	P210: Keep away from – No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof / equipment. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear . P284: Wear respiratory protection. . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a POISON CENTER or doctor/physician. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P320: Specific treatment is urgent (see . on this label). P321: Specific treatment (see . on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P333 + P313: If skin irritation or rash occurs: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P363: Wash contaminated clothing before reuse. P370 + P378: In case of fire: Use for extinction. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.

图形或危害标志
危险性说明	EUH019: May form explosive peroxides. H225: Highly flammable liquid and vapour. H315: Causes skin irritation. H317: May cause an allergic skin reaction. H318: Causes serious eye damage. H330: Fatal if inhaled. H335: May cause respiratory irritation. H351: Suspected of causing cancer ..
防范说明	P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P210: Keep away from – No smoking. P233: Keep container tightly closed. P235: Keep cool. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof ./ equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P260: Do not breathe P261: Avoid breathing P264: Wash thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear . P281: Use personal protective equipment as required. P284: Wear respiratory protection. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P303 + P361 + P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313: IF exposed or concerned: Get medical advice/ attention. P310: Immediately call a POISON CENTER or doctor/physician. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P320: Specific treatment is urgent (see . on this label). P321: Specific treatment (see . on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P333 + P313: If skin irritation or rash occurs: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P363: Wash contaminated clothing before reuse. P370 + P378: In case of fire: Use sand, CO2 or extinguishing powder for extinction. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P403 + P235: Store in a well-ventilated place. Keep cool. P405: Store locked up. P501: Dispose of contents/container to local regulations.