CAS 2413286-32-3; sr-318

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CAS:

2413286-32-3

英文名称:

sr-318

sr 318

sr318

5-amino-n-(4-((3-cyclohexylpropyl)carbamoyl)benzyl)-1-phenyl-1h-pyrazole-4-carboxamide

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货号

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产品名称

规格

包装、参考价格

详情

SML2839

Sigma-Aldrich

SR-318

≥98% (HPLC)

1045.52元/5 MG; 4209.84元/25 MG;

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产品说明

生化/生理作用

SR-318 is a potent and selective type-II inhibitor that targets p38α/β in an inactive DFG-out conformation with good kinome selectivity (p38α/β IC₅₀ = 5/39 nM by radiometric kinase assay). SR-318 selectively inhibits p38α/β by cell-based NanoBRET assay (IC₅₀ = 3.7 nM/p38α, 10 nM/p38β, 0.91 μM/ZAK, ≥3 μM/DDR1, DDR2, KIT, MYLK4, RSK4) and effectively blocks LPS-induced TNF-α release in human whole blood (IC₅₀ = 283 nM). SR-321 is an inactive structural analog and the recommended negative control compound.

基本信息

经验(实验)分子式	C₂₇H₃₃N₅O₂
分子量	459.58

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=C(C(NCC2=CC=C(C(NCCCC3CCCCC3)=O)C=C2)=O)C=NN1C4=CC=CC=C4

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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