| CAS: | 2366255-71-0 | |||
| 分子式: | C17H9ClFN3O2S | |||
| 分子量: | 373.79 | |||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| J936972 | MACKLIN | J30-8 | 98% | 612元/5mg; 2304元/25mg; 6120元/100mg; | 展开 | ||||||||||||||||||||||||||||
储存：2-8°C 状态：白色到米黄色到红棕色粉末 | |||||||||||||||||||||||||||||||||
| SML2688 | Sigma-Aldrich | J30-8 | ≥98% (HPLC) | 941.43元/5 MG; 3793.48元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 J30-8 is a potent c-Jun N-terminal kinase JNK3 subtype-selective inhibtior (human JNK3 IC50 = 40 nM, JNK1α1 & JNK2α2 IC50 >100 μM) that exhibits excellent kinome-wide selectivity (IC50 >7.7 μM against 398 kinase targets) and neuroprotective efficacy against Aβ25-35 toxicity in SH-SY5Y cultures (1 μM). When compared with the pan-JNK inhibitor SP600125 in the APPswe/PS1dE9 murine AD model in vivo (30 mg/kg ip.), J30-8 offers superior therapeutic efficacy and pharmacokinetic properties with longer retention time (elimination t1/2 = 16.11 vs 1.23 hrs; plasma conc = 41 ng/mL vs 22 ng/mL 24 hr post ip.) and greater brain-permeability (brain/plasma ratio = 0.40 vs. 0.14 8 hr post ip.). 基本信息
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