CAS 2362575-45-7; crbn-6-5-5-vhl

CAS:

2362575-45-7

分子式:

C₅₁H₆₉N₇O₁₀S

分子量:

972.20

英文名称:

crbn-6-5-5-vhl

(2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

crbn degrader

crbn directed protac

crbn-vhl hetero-protac

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

C933838

MACKLIN

CRBN-6-5-5-VHL

≥95%

4000元/5mg;

展开

储存：-20°C，干燥，密封

SML3041

Sigma-Aldrich

CRBN-6-5-5-VHL

≥98% (HPLC)

3608.43元/5 MG; 14480元/25 MG;

展开

产品说明

生化/生理作用

CRBN-6-5-5-VHL is a cell-permeable and highly potent heterodimerizer comprising E3 ligases recruiting ligands, namely, pomalidomide and VH032-amine that efficiently knocks down Cereblon (CRBN). CRBN-6-5-5-VHL readily forms heteroternary complex and selectively induces CRBN ubiquitination and proteasomal degradation over VHL in a time- and dose-dependent fashion (0.001 to 1 μM). Higher concentrations (10 μM) causes the degradation of neo-substrates IKZF1 and IKZF3 with no effect on pVHL30 or pVHL19 levels.

基本信息

经验(实验)分子式	C₅₁H₆₉N₇O₁₀S
分子量	972.20
MDL编号	MFCD32705129

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	O=C1C2=C(C=CC=C2C(N1C3C(NC(CC3)=O)=O)=O)NCCCCCCOCCCCCOCCCCC(N[C@H](C(N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)=O)C(C)(C)C)=O