| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| C797862 | MACKLIN | 克霉唑 | 10mM in DMSO | 468元/1ml; | 展开 |
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| C2867 | TCI | Clotrimazole | >98.0%(T)(HPLC) | 80元/5G; 190元/25G; | 展开 |
基本信息 | 纯度/分析方法 | >98.0%(T)(HPLC) | | 分子式/分子量 | C22H17ClN2 = 344.84 | | 外观与形状(20℃) | 固体 | | Reaxys-RN | 622318 | | PubChem物质ID | 253661533 | | Merck Index (14) | 2417 | | MDL编号 | MFCD00057220 |
技术规格 | Appearance | White to Almost white powder to crystal | | Purity(HPLC) | min. 98.0 area% | | Purity(Nonaqueous Titration) | min. 98.0 % | | Melting point | 144.0 to 148.0 ℃ |
物性(参考值) | 熔点 | 147 ℃ | | 最大吸收波长 | 556(Phosphate buffer sol.) nm | | 水溶性 | 不溶 | | 溶解性(易溶于) | 二氯甲烷 | | 溶解性(可溶于) | 二甲基甲酰胺,甲醇,乙醇 | | 溶解度(极微溶) | 乙醚 |
安全信息 | 图形或危害标志 |  | | 信号词 | 警告 | | 危险性说明 | H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H413 : 可能对水生生物造成长期持续有害影响。
| | 防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。
P273 : 避免释放到环境中。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
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相关法规 |
| 496300 | J&K | Clotrimazole | 99% | 133元/1G; 465元/5G; | 展开 |
基本信息 | 分子式 | C22H17ClN2 | | 分子量 | 344.84 | | MDL编码 | MFCD00057220 | | EINECS 编号 | 245-764-8 |
安全信息 | 图形或危害标志 | | | 提示语 | Warning | | 危险说明 | H302
H315
H319 | | 防范说明 | P305+P351+P338 | | WGK | 3 | | RTECS | NI4377000 |
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| PHR1058 | Supelco | Clotrimazole | Pharmaceutical Secondary Standard; Certified Reference Material | 1162.78元/1 G; | 展开 |
产品说明 一般描述 Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clotrimazole is an imidazole antifungal agent with relatively low toxicity. It is widely used in dermatology and gynaecology applications. Clotrimazole ointments are extensively utilized for the treatment of a wide range of systemic mycoses including candidiasis. 应用 These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Clotrimazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques. 分析说明 These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. 其他说明 This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. 附注 To see an example of a Certificate of Analysis for this material enter LRAA7129 in the slot below. This is an example certificate only and may not be the lot that you receive. 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | EC 号 | 245-764-8 | | MDL编号 | MFCD00057220 | | PubChem化学物质编号 | 329823088 | | NACRES | NA.24 |
产品性质 | 质量水平 | 300 | | 等级 | certified reference material
pharmaceutical secondary standard | | CofA | current certificate can be downloaded | | technique(s) | HPLC: suitable
gas chromatography (GC): suitable | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 药典可追溯性 | traceable to BP 379
traceable to PhEur C2430000
traceable to USP 1141002 | | 储存温度 | 2-30℃ | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
安全信息 | 象形图 |  | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| C2430000 | | Clotrimazole | European Pharmacopoeia (EP) Reference Standard | 1572.27元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | MDL编号 | MFCD00057220 | | PubChem化学物质编号 | 329775002 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| Y0000849 | | Clotrimazole for peak identification | European Pharmacopoeia (EP) Reference Standard | 1572.27元/ ; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 1.005 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. 注意 Please find SDS provided by EDQM here.. 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | MDL编号 | MFCD00057220 | | PubChem化学物质编号 | 329831188 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | EDQM | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| C6019 | Sigma-Aldrich | Clotrimazole | | 1255.34元/5 G; 3446.51元/25 G; 8743.5元/100 G; | 展开 |
产品说明 一般描述 化学结构：咪唑 应用 克霉唑已被用于：
- 在假丝酵母中，研究用唑类抗生素处理后，编码唑类靶酶羊毛甾醇脱甲基酶的基因ERG11的上调
- 研究从长期抗真菌治疗的患者中分离的假丝酵母的耐药性的发展
- 通过线粒体应激诱导应激颗粒
- 抑制1-氯-2,4-二硝基苯(CDNB)处理诱导的高密度镰状细胞的体外形成
- 在细胞培养物中抑制细胞色素P450酶
生化/生理作用 克霉唑是一种Ca2+-活化的K+ 通道的特异性抑制剂。 它是一种抗真菌的唑类。克霉唑是一种咪唑的衍生物，具有与酮康唑相似的抗微生物作用和活性。 它可抑制细胞色素P450依赖性14α -去甲基化酶，这对麦角甾醇生物合成至关重要。累积的14α -甲基化甾醇可改变敏感真菌的膜结构，同时改变细胞膜的通透性。 特点和优势 该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
该化合物出现在受体分类和信号转导手册的钾离子通道页。欲浏览其他手册页，点击此处。 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | EC 号 | 245-764-8 | | MDL编号 | MFCD00057220 | | PubChem化学物质编号 | 24278327 | | NACRES | NA.77 |
产品性质 | 质量水平 | 200 | | 作用机制 | cell membrane | interferes
protein synthesis | interferes | | 抗生素抗菌谱 | fungi | | 创始人 | Schering Plough | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N | | Gene Information | human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| BP379 | | Clotrimazole | British Pharmacopoeia (BP) Reference Standard | 1897.81元/100 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. 包装 Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia 其他说明 Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | EC 号 | 245-764-8 | | MDL编号 | MFCD00057220 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | BP | | 格式 | neat | | 储存温度 | 2-8℃ | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| 1141002 | USP | Clotrimazole | United States Pharmacopeia (USP) Reference Standard | 2633.96元/200 MG; | 展开 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C22H17ClN2 | | 分子量 | 344.84 | | MDL编号 | MFCD00057220 | | PubChem化学物质编号 | 329749440 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | SMILES string | Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 | | InChI | 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | | InChI key | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H302 - H315 - H319 - H410 | | 预防措施声明 | P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 | | 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 |
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| 492467 | Fluorochem | Clotrimazole | = 99% (TLC) | 286元/1g; 616元/5g; 1760元/25g; 4620元/100g; | 展开 |
基本信息 | CAS Number | 23593-75-1 | | MDL Number | MFCD00057220 | | Melting Point | 147℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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