CAS 23363-64-6; chlorflavonin

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CAS:

23363-64-6

英文名称:

chlorflavonin

2-(3-chloro-2-hydroxyphenyl)-5-hydroxy-3,7,8-trimethoxy-4h-1-benzopyran-4-one

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货号

品牌

产品名称

规格

包装、参考价格

详情

SML2297

Sigma-Aldrich

Chlorflavonin

≥98% (HPLC)

999.93元/5 MG; 4036.8元/25 MG;

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产品说明

生化/生理作用

Originally isolated from Aspergillus candidus Link, Chlorflavonin is a non-cytotoxic (up to 100 μM; MRC-5 and THP-1) antibiotic with antifungal activity against certain species of mold fungi (MIC = 0.08 μg/mL against A. amstelodami, A. fumigalus, A. ochraceous; Paecilomyces variotii MIC = 2.5 μg/mL, Botrytis cinerea MIC = 5 μg/mL). Chlorflavonin also exhibits antibiotic activity against M. tuberculosis (MIC90 = 1.56 μM) by targeting acetohydroxyacid synthase (AHAS) catalytic subunit ilvB1. Chlorflavonin is superior to streptomycin against M. tuberculosis inside infected macrophages, synergizes with isoniazid and delamanid, leading to a complete sterilization in liquid cultures.

基本信息

经验(实验)分子式	C₁₈H₁₅ClO₇
分子量	378.76

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	OC1=CC(OC)=C(C2=C1C(C(OC)=C(C3=C(O)C(Cl)=CC=C3)O2)=O)OC
InChI	1S/C18H15ClO7/c1-23-11-7-10(20)12-14(22)18(25-3)15(26-17(12)16(11)24-2)8-5-4-6-9(19)13(8)21/h4-7,20-21H,1-3H3
InChI key	JLSQXYITDXJTKL-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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