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CAS: 23256-50-0
分子式: C10H12Cl2N4O2
分子量: 291.13
熔点: 227-229 °C
英文名称: 
((2,6-dichlorobenzylidene)amino)-guanidin monoacetate
((2,6-dichlorobenzylidene)amino)guanidine acetate
br 750
guanabenz
guanabenz acetate
2-((2,6-dichlorophenyl)methylene)-hydrazinecarboximidamid monoacetate
wy 8678 acetate
推荐供应商
货号品牌产品名称规格包装、参考价格详情
G859761MACKLIN乙酸胍那苄≥98%140元/1g;   610元/5g;   2199元/25g;  
储存:2-8°C
状态:白色到浅黄色粉末到晶体
G793951MACKLIN乙酸胍那苄10mM in DMSO269元/1ml;  
储存:-20°C
G0456TCIGuanabenz Acetate>98.0%(T)(HPLC)290元/200MG;   990元/1G;  

基本信息

纯度/分析方法>98.0%(T)(HPLC)
分子式/分子量C8H8Cl2N4・C2H4O2 = 291.13
外观与形状(20℃)固体
应避免的情况
相关CAS RN5051-62-7
Reaxys-RN4169995
PubChem物质ID253660672
Merck Index (14)4558
MDL编号MFCD00153801

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(HPLC)min. 98.0 area%
Purity(Nonaqueous Titration)min. 98.0 %
Melting point188.0 to 192.0 ℃

物性(参考值)

熔点190 ℃
水溶性微溶
在水中的溶解度11 g/l   25 ℃
溶解性(可溶于)
溶解度(极微溶)氯仿

安全信息

图形或危害标志
信号词危险
危险性说明H301 : 吞咽会中毒。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P310 + P330 : 如误吞咽:立即呼叫急救中心/医生。漱口。
P405 : 存放处须加锁。

相关法规

RTECS#MF0382000

运输信息

UN编号UN2811
类别6.1
包装类别 III
监管条件代码(*)
999718J&KGuanabenz Acetate97%1500元/10G;  

基本信息

分子式C8Cl2H8N4
分子量291.13
MDL编码MFCD00153801
G110Sigma-AldrichGuanabenz acetate saltpowder624.54元/25 MG;   1399.43元/100 MG;   5007.85元/500 MG;  

产品说明

包装

25 mg in poly bottle
100, 500 mg in glass bottle

生化/生理作用

中枢作用的α2 肾上腺素能受体激动剂;I2 咪唑啉结合位点配体;抗高血压活性。

特点和优势

该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里 。
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物出现在受体分类和信号转导手册的α2-肾上腺素受体和咪唑啉结合位点页。要浏览手册其他页,点击此处。

基本信息

经验(实验)分子式C8H8Cl2N4 · C2H4O2
分子量291.13
EC 号245-534-7
MDL编号MFCD00153801
PubChem化学物质编号24277775
NACRESNA.77

产品性质

形式powder
质量水平200
颜色 white
溶解性H2O: 10 mg/mL
alcohol: 50 mg/mL
创始人Wyeth
SMILES stringCC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl
InChI1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChI keyMCSPBPXATWBACD-GAYQJXMFSA-N
Gene Informationhuman ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves
1301404USPGuanabenz AcetateUnited States Pharmacopeia (USP) Reference Standard3036.37元/200 MG;  

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

中枢作用的α2 肾上腺素能受体激动剂;I2 咪唑啉结合位点配体;抗高血压活性。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C8H8Cl2N4 · C2H4O2
分子量291.13
MDL编号MFCD00153801
PubChem化学物质编号329749972

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC(O)=O.NC(=N)N\N=C\c1c(Cl)cccc1Cl
InChI1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChI keyMCSPBPXATWBACD-GAYQJXMFSA-N
Gene Informationhuman ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
370625Sigma-AldrichGuanabenz Acetate-CAS 23256-50-0-CalbiochemA cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.2209元/100 mg;  

产品说明

一般描述

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.

包装

250 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C8H8Cl2N4 · xC2H4O2
分子量231.08 (free base basis)
MDL编号MFCD00153801

产品性质

质量水平100
测定≥99% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 white
溶解性water: 5 mg/mL
运输ambient
储存温度2-8℃
InChI1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChI keyMCSPBPXATWBACD-GAYQJXMFSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P264 - P270 - P301 + P310 - P405 - P501
危险分类Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
386760FluorochemGuanabenz Acetate98%2200元/1g;   7700元/5g;   13200元/10g;   23760元/25g;  

基本信息

CAS Number23256-50-0
MDL NumberMFCD00153801
Melting Point190℃

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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