CAS 22910-60-7; ginkgolic acid

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

G810552

MACKLIN

银杏酸(C15:1)

98%

1200元/5mg; 1630元/10mg; 3450元/25mg;

展开

储存：2-8 °C, 密封, 干燥, 避光

146397

J&K

Ginkgolic acid

98%, 来源于银杏果

3065元/5MG;

展开

基本信息

分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编码	MFCD03093717
存储条件	Freezer -20℃

安全信息

图形或危害标志
提示语	Warning
危险说明	H315 H319 H335
防范说明	P261 P305+P351+P338
WGK	3

5.08197

Sigma-Aldrich

InSolution Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

2313.1元/2 mg;

展开

产品说明

一般描述

A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC₅₀ = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.

生化/生理作用

Cell permeable: yes
Primary Target
SUMO-activating enzyme E1
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 25 mM (2 mg/231 µl) sterile-filtered solution of Ginkgolic Acid (15:1) (Cat. No. 345887) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.

其他说明

Fukuda, I., et al. 2009. Chem. Biol.16, 133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编号	MFCD03093717

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
储存温度	−70℃
InChI	1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key	YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	188.6 °F - (refers to pure substance)
闪点(C)	87 ℃ - (refers to pure substance)

345887

Sigma-Aldrich

Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

A cell-permeable anacardic acid analog that inhibits protein SUMO .

5238.04元/5 MG;

展开

产品说明

一般描述

A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC₅₀ = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).
A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC₅₀ = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

重悬

Following intitial thaw, aliquot and freeze (-20°C).

其他说明

Fukuda, I., et al. 2009. Chem. Biol.16, 133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编号	MFCD03093717

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 100 mg/mL ethanol: 100 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key	YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H413
预防措施声明	P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
危险分类	Aquatic Chronic 4 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	509.9 °F - (calculated)
闪点(C)	265.5 ℃ - (calculated)

75741

Supelco

Ginkgolic acid C15:1

analytical standard

4911.34元/5 MG;

展开

产品说明

一般描述

银杏酸C15:1 是一种烷基酚，属于从银杏叶中分离的银杏酸类。它还具有很强的致敏性，以及致癌和致突变活性。

应用

有关合适仪器技术的更多信息，请参考产品′s分析证书。如需进一步支持，请联系技术服务。
银杏酸C15:1可用作参考标准品，用于通过高效液相色谱-质谱联用(HPLC-MS)测定银杏(Ginkgolic)提取物中烷基酚(如银杏酸)的含量。
银杏酸C15:1可用作参考标准品，用于通过高效液相色谱-质谱联用法(HPLC-MS)定量测定银杏(Ginkgolic)提取物中的烷基酚(如银杏酸)。
银杏酸 C15:1 可用作分析参考标准品，用于通过色谱技术定量测定银杏植物提取物和膳食补充剂中的分析物。

基本信息

经验(实验)分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编号	MFCD03093717
PubChem化学物质编号	329766672

产品性质

等级	analytical standard
质量水平	100
测定	≥80% (HPLC)
保质期	limited shelf life, expiry date on the label
technique(s)	HPLC: suitable gas chromatography (GC): suitable
application(s)	food and beverages
格式	neat
储存温度	2-8℃
SMILES string	CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O
InChI	1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key	YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H413
预防措施声明	P273 - P280 - P302 + P352
危险分类	Aquatic Chronic 4 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	509.9 °F - (calculated)
闪点(C)	265.5 ℃ - (calculated)
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

PHL89522

Ginkgolic acid C15:1

phyproof^® Reference Substance

10540.3元/10 MG;

展开

产品说明

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

基本信息

经验(实验)分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编号	MFCD03093717

产品性质

等级	primary reference standard
产品线	phyproof^® Reference Substance
测定	≥95.0% (HPLC)
形式	solid
manufacturer/tradename	PhytoLab
储存温度	2-8℃
SMILES string	CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O
InChI	1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key	YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H413
预防措施声明	P273 - P280 - P302 + P352
危险分类	Aquatic Chronic 4 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	509.9 °F - (calculated)
闪点(C)	265.5 ℃ - (calculated)

078741

Fluorochem

Ginkgolic acid I

95%

22374元/250mg;

展开

基本信息

CAS Number	22910-60-7
MDL Number	MFCD03093717