| CAS: | 228559-41-9 | |
| 分子式: | C24H18F3N3O4 | |
| 分子量: | 469.41 | |
| 沸点: | 497.07°C at 760 mmHg | |
| 熔点: | 235-238°C | |
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||
| K794056 | MACKLIN | Ki8751 | 10mM in DMSO | 507元/1ml; | 展开 | ||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||
| K855194 | MACKLIN | Ki8751 | 98% | 290元/5mg; 750元/25mg; 970元/100mg; | 展开 | ||||||||||||||||||||||||||||||||
储存： -20°C 状态：白色到灰白色固体 | |||||||||||||||||||||||||||||||||||||
| 676484 | Sigma-Aldrich | VEGFR2 Kinase Inhibitor VI, Ki8751-CAS 228559-41-9-Calbiochem | The VEGFR2 Kinase Inhibitor VI, Ki8751, also referenced under CAS 228559-41-9, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation &a | 3945.15元/5 MG; | 展开 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRα, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo. 包装 5 mg in Plastic ampoule 警告 Toxicity: Regulatory Review (Z) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 其他说明 Kubo, K., et al. 2005. J. Med. Chem.48, 1359. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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