CAS 22816-60-0; a22 盐酸盐; a22 hydrochloride

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货号

品牌

产品名称

规格

包装、参考价格

M912252

MACKLIN

MreB Perturbing Compound A22

98%

805元/10mg;

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储存：-20°C，密闭，干燥

SML0471

Sigma-Aldrich

A22 hydrochloride

≥95% (HPLC)

1118.38元/10 MG; 3620元/50 MG;

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产品说明

应用

A22盐酸已被用于研究其抗生物膜活性、抗菌、细胞和遗传毒性活性。它也可作为MreB聚合抑制剂用于了解MreB聚合物在白色念珠菌和高假丝酵母念珠菌中的作用。

包装

10, 50 mg in glass bottle

生化/生理作用

A22是肌动蛋白样细菌蛋白MreB的一种抑制剂，已被证明可作为抗菌佐剂。A22对MreB的抑制作用可破坏细菌肌动蛋白的细胞骨架，导致细胞通透性增加和干扰转运。A22已显示出与革兰氏阴性细菌中的数种抗生素具有协同作用，包括新生霉素和利福平。

基本信息

经验(实验)分子式	C₈H₈Cl₂N₂S · HCl
分子量	271.59
MDL编号	MFCD00035050
PubChem化学物质编号	329825427
NACRES	NA.77

产品性质

测定	≥95% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL (clear solution, warmed)
储存温度	2-8℃
SMILES string	Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
InChI	1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key	VBJNMXMOMSWRDV-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

475951

Sigma-Aldrich

MreB Perturbing Compound A22-CAS 22816-60-0-Calbiochem

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

1940.38元/25 MG;

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产品说明

一般描述

A cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB′s nucleotide binding pocket and is useful for the temporal analysis of MreB function.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Primary Target
MreB

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.

其他说明

Gitai, Z., et al. 2005. Cell120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₈H₈Cl₂N₂S · xHCl
分子量	235.13 (free base basis)
MDL编号	MFCD00035050

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	water: 2 mg/mL DMSO: 200 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key	VBJNMXMOMSWRDV-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

047313

Fluorochem

2-(3,4-Dichloro-benzyl)-isothiourea hydrochloride

95%

1210元/250mg; 2816元/1g; 11550元/5g;

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基本信息

CAS Number	22816-60-0
MDL Number	MFCD00035050
Melting Point	237-239℃

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.