CAS 2275601-87-9; mu1210

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CAS:

2275601-87-9

英文名称:

mu1210

1-methyl-4-(9-(3-(pyridin-4-yl)-phenyl)-7-oxa-2-aza-bicyclo[4.3.0]nona-1,3,5,8-tetraen-3-yl)-1h-pyrazole

5-(1-methyl-1h-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine

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货号

品牌

产品名称

规格

包装、参考价格

SML2713

Sigma-Aldrich

MU1210

≥98% (HPLC)

1364.72元/5 MG; 5262.3元/25 MG;

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产品说明

生化/生理作用

MU1210 is a potent and selective inhibitor against cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4 (CLK1/2/4 IC₅₀ = 8/20/12 nM; CLK1/2/4 K_i = 84/91/23 nM by NanoBRET) and HIPK2 (IC₅₀ = 29 nM) with good selectivity over HIPK1/3 (IC₅₀ = 187/159 nM), DYRK1a/1b/2 (IC₅₀ = 213/956/1309 nM), CLK3 (IC₅₀ >3 μM) and 194 other kinases. MU1210 enhances alternative spliced MDM4-S mRNA (10 μM, 24 h) and exhibits antiproliferation activity in MCF7 cultures (IC₅₀ in 72 h = 1.1 μM). Unlike most ATP site-targeting kinase inhibitors, X-ray crystallography shows that MU1210 is anchored to the back pocket instead of the hinge region of CLK1. MU140 serves as a negative control.

基本信息

经验(实验)分子式	C₂₂H₁₆N₄O
分子量	352.39

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	CN(N=C1)C=C1C2=CC=C3C(C(C4=CC=CC(C5=CC=NC=C5)=C4)=CO3)=N2

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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