CAS 2250091-96-2; (S)-n,n′-(decane-1,10-diyl)bis(2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f] [1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide); ms645

CAS:

2250091-96-2

分子式:

C₄₈H₅₄Cl₂N₁₀O₂S₂

分子量:

938.04

中文名称:

(S)-n,n′-(decane-1,10-diyl)bis(2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f] [1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamide)

英文名称:

ms645

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

M933748

MACKLIN

MS645

≥98%

2500元/10mg;

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储存：-20°C，惰性气体保存

SML2549

Sigma-Aldrich

MS645

≥98% (HPLC)

1330.03元/5 MG; 5366.38元/25 MG;

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产品说明

生化/生理作用

MS645 is a cell penetrant bivalent bromodomain (BRD) inhibitor that inhibits the tandem BD1/BD2 of BRD4. It potently represses BRD4 transcriptional activity in solid-tumor cells including TNBC. MS645 potently inhibits IL-6 expression MDA-MB-231 cells. MS645 exhibits sustained blockade of BRD4 by inhibition of BRD4 interactions with transcription enhancer/mediator proteins MED1 and YY1.

基本信息

经验(实验)分子式	C₄₈H₅₄Cl₂N₁₀O₂S₂
分子量	938.04

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCCCCCCCCCCNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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