CAS 22494-42-4; 二氟苯水杨酸; 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic aci

推荐供应商
货号品牌产品名称规格包装、参考价格详情
D795491MACKLIN二氟苯水杨酸10mM in DMSO140元/1ml;   
储存：-20°C
D832908MACKLIN二氟苯水杨酸≥98%29元/1g;   99元/5g;   420元/25g;   
储存：室温,干燥,密封
状态：白色固体
D5875TCIDiflunisal>98.0%(GC)450元/5G;   1550元/25G;   
基本信息
纯度/分析方法>98.0%(GC)
分子式/分子量C13H8F2O3 = 250.20
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN2654431
Merck Index (14)3146
MDL编号MFCD00057834
技术规格
AppearanceWhite to Almost white powder to crystaline
Purity(GC)min. 98.0   %
Melting point211.0   to 215.0    ℃
Solubility in Methanolalmost transparency
物性(参考值)
熔点215 ℃
最大吸收波长253(H2O) nm
安全信息
图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染：用水充分清洗。
P337 + P313 : 如仍觉眼刺激：求医/就诊。
P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激：求医/就诊。
P301 + P312 + P330 : 如误吞咽：如感觉不适，呼叫急救中心/医生。漱口。
相关法规
RTECS#DV2030000
154153J&KDiflunisal98%, 一种水杨酸盐衍生物, 具有非甾体抗炎和尿酸舒缓性能, 可单独用作止痛剂和类风湿关节炎患者636元/100MG;   1335元/500MG;   
基本信息
分子式C13H8F2O3
分子量250.20
熔点212.1-214.9
沸点249
密度1.437
折光率(n20D)1.601
MDL编码MFCD00057834
存储条件Freezer -20℃
产品描述
Diflunisal是水杨酸的二氟苯基衍生物，是非类固醇的消炎药。具有退热、止痛和消炎特性。它是环氧酶抑制剂。
靶点（IC50 & Targe）
p300,996μM
体外研究
Diflunisal是含有水杨酸亚结构的FDA批准的药物。比起水杨酸盐，diflunisal更能有效抑制CBP/p300。Diflunisal对特定类型的白血病（带有t(8;21)易位）具有抗肿瘤活性[2]。
体内研究
Diflunisal所介导的限速甲状腺素运载蛋白的动力学稳定能其减缓淀粉样变性[3]。
细胞实验
Cell lines: HEK293T cells
Concentrations: 0, 100, 200, 400 μM
Incubation Time: 24 h
Method:用野生型p300或无催化活性的p300突变体的表达载体转染HEK293T细胞，转染24小时后，用diflunisal处理转染细胞24小时。用western blot检测H2B乙酰化情况。
(Only for Reference)
动物实验
Animal Models: Female Sprague-Dawley rats, Female New Zealand White Rabbits
Formulation: 0.5% 甲基纤维素
Dosages: 250 mg/kg
Administration: 口服
(Only for Reference)
参考文献
[1] Cappon GD, et al. Birth Defects Res B Dev Reprod Toxicol. 2003, 68(1):47-56.
[2] Shirakawa K, et al. Elife. 2016, 5. pii: e11156.
[3] Sekijima Y, et al. Amyloid. 2006, 13(4):236-49.
安全信息
图形或危害标志
提示语Warning
危险说明H302
H410
防范说明P264
P270
P273
P301+P312
P330
P391
P501
UN号码3077
危险分类9
包装等级III
WGK3
RTECSDV2030000
Y10567Alfa AesarDiflunisal161元/1g;   354元/5g;   623元/10g;   1334元/25g;   
基本信息
分子量
250.2
D1750000DiflunisalEuropean Pharmacopoeia (EP) Reference Standard1544.34元/30 mg;   
产品说明
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
包装
Unit quantity: 30 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
注意
Please find SDS provided by EDQM here..
其他说明
Sales restrictions may apply.
基本信息
经验(实验)分子式C13H8F2O3
分子量250.20
MDL编号MFCD00057834
PubChem化学物质编号329798707
NACRESNA.24
产品性质
等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringFC1=CC(F)=CC=C1C2=CC(C(O)=O)=C(O)C=C2
InChI1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)
InChI keyHUPFGZXOMWLGNK-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)
安全信息
象形图
警示用语：Warning
危险声明H302 - H315 - H319 - H335 - H361
预防措施声明P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
D3281SupelcoDiflunisalanalytical standard537.62元/5 G;   
产品说明
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
包装
5 g in poly bottle
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D3281.pdf    Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
经验(实验)分子式C13H8F2O3
分子量250.20
EC 号245-034-9
MDL编号MFCD00057834
PubChem化学物质编号329798693
产品性质
等级analytical standard
质量水平100
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)forensics and toxicology
pharmaceutical (small molecule)
格式neat
SMILES stringFC1=CC(F)=CC=C1C2=CC(C(O)=O)=C(O)C=C2
InChI1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)
InChI keyHUPFGZXOMWLGNK-UHFFFAOYSA-N
Gene Informationhuman ... ALB(213), PTGS1(5742), PTGS2(5743)
安全信息
象形图
警示用语：Warning
危险声明H302 - H315 - H319 - H335 - H361
预防措施声明P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
1197506USPDiflunisalUnited States Pharmacopeia (USP) Reference Standard3036.37元/200 MG;   
产品说明
一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​
其他说明
USP issued SDS can be found here.
Sales restrictions may apply.
基本信息
经验(实验)分子式C13H8F2O3
分子量250.20
MDL编号MFCD00057834
PubChem化学物质编号329749587
产品性质
等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringFC1=CC(F)=CC=C1C2=CC(C(O)=O)=C(O)C=C2
InChI1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)
InChI keyHUPFGZXOMWLGNK-UHFFFAOYSA-N
Gene Informationhuman ... PTGS1(5742), PTGS2(5743)
安全信息
象形图
警示用语：Warning
危险声明H302 - H315 - H319 - H335 - H361
预防措施声明P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
031599Fluorochem2',4'-Difluoro-4-hydroxy-biphenyl-3-carboxylic acid0.98220元/1g;   440元/5g;   704元/10g;   1540元/25g;   
基本信息
CAS Number22494-42-4
MDL NumberMFCD00057834
安全信息
图形或危害标志
危险性说明        H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明        P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .