| CAS: | 2243000-24-8 | ||
| 分子式: | C23H29N3O6 | ||
| 分子量: | 433.49 | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||
| P958967 | MACKLIN | 泊马度胺-C9-酸 | ≥95% | 654元/5mg; | 展开 | ||||||||||||||||||||||||||
储存：2-8°C, 密封, 干燥 状态：深黄色粉末或晶体 | |||||||||||||||||||||||||||||||
| 901525 | Sigma-Aldrich | Pomalidomide-C9-CO2H | ≥95% | 5263.89元/50 MG; | 展开 | ||||||||||||||||||||||||||
产品说明 应用 Protein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. 其他说明 Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradationn 法律信息 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license 基本信息
产品性质
安全信息
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