CAS 2230640-94-3; tt-10

位置：首页 > 资料中心 > 化工字典 > 2230640-94-3

CAS:

2230640-94-3

英文名称:

tt-10

[4-amino-2-(2-propen-1-ylamino)-5-thiazolyl](5-fluoro-2-thienyl)methanone

n2-allyl-5-[(5-fluorothiophen-2-yl)carbonyl]thiazole-2,4-diamine

tt 10

taz-k

taz k

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

SML2658

Sigma-Aldrich

TT-10

≥98% (HPLC)

1174.92元/5 MG; 4736.14元/25 MG;

咨询

产品说明

生化/生理作用

TT-10 (TAZ K) is a TAZ (transcriptional coactivator with PDZ-binding motif) activator that promotes cardiomyocytes (CMs) proliferation (fold-increase by 10 μM TT-10 over untreated control = 5.2/rat CMs/40 hrs & 2.6/human iPSC-derived CMs/48 hrs) by activating YAP (YES-associated protein)/TEAD (transcriptional enhancer factor domain) complex-mediated transcription, as well as by exerting antioxidant and antiapoptotic activity. TT-10 ameliorates myocardial infarction-induced cardiac dysfunction in mice in vivo (10 mg/kg i.p.) at least in part via enhancing clonal expansion of existing cardiomyocytes with nuclear YAP expression.

基本信息

经验(实验)分子式	C₁₁H₁₀FN₃OS₂
分子量	283.35

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=C(C(C2=CC=C(S2)F)=O)SC(NCC=C)=N1

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9