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CAS: 2226-96-2
分子式: C9H18NO2
分子量: 172.24
熔点: 69-71℃
中文名称: 
4-羟基-2,2,6,6-四甲基哌啶氧(自由基)
4-羟基-2,2,6,6-四甲基哌啶-1-氧自由基
阻聚剂701
2,2,6,6-四甲基哌啶氮氧自由基
阻聚剂-701
氮氧自由基哌啶醇
阻聚剂ZJ-701
四甲基哌啶酮
英文名称: 
High-effective Inhibitor701
1-Piperidinyloxy,4-hydroxy-2,2,6,6-tetramethyl-
4-hydroxy-2,2,6,6-tetramethyl-1-Piperidinyloxy
4-hydroxy-2,2,6,6-tetramethyl-piperidinoox
4-hydroxy-2,2,6,6-tetramethyl-1-piperidinylox
2,2,6,6-tetramethyl-4-piperidinol-n-oxyl
4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy
4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl
4-oxypiperidol
nitroxyl 2
nr 1
tanol
tempol
4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl
tetramethylpiperidinol n-oxyl
tmpn
4-hydroxy-2,2,6,6-tetramethyl-piperidinooxy
4-Hydroxy-2,2,6,6-tetramethyl-piperidinyloxy
4-hydroxy-2,2,6,6,-tetramethylpiperimyloxy
4-hydroxy-tempo
4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl
4-Hydroxy-TEMPO,free radical
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy,free radical
4-Oxo-2,2,6,6-tetramethylpiperidine(4-Amino-TEMP)
4-Hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxide
4-Hydroxy-2,2,6,6-tetramethyl-piperidine 1-oxide
展开更多英文名
性质描述: 易溶于乙醇、苯等有机溶剂,易溶于水。
用途: 该品对丙烯酸酯类、甲基丙烯酸酯类、丙烯酸、丙烯腈、苯乙烯、丁二烯有较好的阻聚效果。其阻聚性能优于酚类、芳胺类、醚类、醌类和硝基化合物等阻聚剂。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
H796040MACKLIN氮氧自由基哌啶醇10mM in DMSO165元/1ml;   展开
储存:-20°C
H810913MACKLIN氮氧自由基哌啶醇98%28元/1g;   30元/5g;   39元/25g;   78元/100g;   296元/500g;   855元/2.5kg;   展开
储存:2~8°C
状态:黄色到橙色晶体或粉末或片状或块状
H0865TCI4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical>98.0%(GC)200元/5G;   620元/25G;   展开

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C9H18NO2 = 172.25
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况光,湿气 (吸湿)
Reaxys-RN11328213
PubChem物质ID87571222
Merck Index (14)9141
MDL编号MFCD00006478

技术规格

AppearanceLight yellow to Amber to Dark green powder to crystal
Purity(GC)min. 98.0 %
Purity(Iodometric Titration)min. 97.0 %
Melting point69.0 to 75.0 ℃
Solubility in Methanolvery faint turbidity

物性(参考值)

熔点72 ℃
水溶性可溶
溶解性(可溶于)甲醇

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#TN8991000
609412J&K4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy98%, 自由基60元/1G;   166元/5G;   551元/25G;   展开

基本信息

分子式C9H18NO2
分子量172.25
沸点69-73
MDL编码MFCD00006478
Beilstein1422990
Merck14,9141
EINECS 编号218-760-9

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
防范说明P280
P301+P312
P302+P352
P305+P351+P338
WGK1
RTECSTN8991000
TSCA
983983J&K4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy99%736元/250G;   展开

基本信息

分子式C9H18NO2
分子量172.25
沸点69-73
MDL编码MFCD00006478
Beilstein1422990
Merck14,9141
EINECS 编号218-760-9

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
防范说明P280
P301+P312
P302+P352
P305+P351+P338
WGK1
RTECSTN8991000
TSCA
A12497Alfa Aesar4-Hydroxy-TEMPOfree radical, 98+%299元/1g;   885元/5g;   3769元/25g;   展开

应用
Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.

备注
Store in a cool place. Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00006478

EINECS
218-760-9

分子式
C9H18NO2

分子量
172.25

熔点
69-72°

闪点
146°(295°F)

灵敏度
Keep Cold.

形态
Crystalline powder

溶解性
Soluble in water, ethanol, methanol and dimethyl sulfoxide.

Beilstein
1422990

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H315-H318-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye damage.May cause respiratory irritation.

Precautionary Statements
P280-P305+P351+P338-P310
Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Immediately call a POISON CENTER or doctor/physician.

安全信息

危险类别
22-37/38-41
Harmful if swallowed.Irritating to respiratory system and skin.Risk of serious damage to eyes.

安全等级
26-36/37/39-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
TN8991000

TSCA

C17505Alfa Aesar4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy98%, free radical564元/1g;   1088元/5g;   4682元/25g;   展开

基本信息

Ref#
17505

MDL
6478

分子式
C9 H18 N O2

分子量
172.25

形态
Orange cryst powder

176141Sigma-Aldrich4-Hydroxy-TEMPO97%335.87元/1 G;   900.12元/5 G;   3688.69元/25 G;   展开

产品说明

一般描述

4-羟基-TEMPO是4-取代的2,2,6,6-四甲基哌啶-1-氧(TEMPO)衍生物。它是一种低分子量化合物,已被建议作为超氧化物歧化酶模拟物。

应用

由衍生化TEMPO丙炔醚以及随后与氟叠氮化物发生"点击"反应,制备氟标记的TEMPO衍生物。该TEMPO衍生物已被证明是用漂白剂氧化醇的高效催化剂。
用于研究生物化合物 和聚合物的自旋标记物。
4-羟基-TEMPO(HO-TEMPO)可用作催化剂将醇氧化成相应的醛。它可用于制备TEMPO聚合物催化体系,该体系可用于多种伯醇的Anelli氧化。它可以用作合成4-(2,2,6,6-四甲基-1-氧基-4-哌啶氧基)丁基溴的起始试剂。
自旋标记试剂,用于鉴定 NK1 受体的拮抗剂和激动剂结合位点。也可用于电子自旋共振光谱法测定心肌中活性氧的生成。TEMPOL 可保护过量表达 CYP2E1 的细胞免受花生四烯酸的毒性损伤。

包装

1, 5, 25 g in glass bottle

基本信息

经验(实验)分子式C9H18NO2
分子量172.24
Beilstein1422990
EC 号218-760-9
MDL编号MFCD00006478
PubChem化学物质编号24850555
NACRESNA.22

产品性质

质量水平200
测定97%
组成Carbon content, 60.6-65.0%
Nitrogen content, 7.8-8.4%
mp69-71 ℃ (lit.)
储存温度2-8℃
SMILES stringCC1(C)CC(O)CC(C)(C)N1[O]
InChI1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI keyUZFMOKQJFYMBGY-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07
警示用语:Danger
危险声明H302 - H318
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
危险分类Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)294.8 °F - DIN 51758
闪点(C)146 ℃ - DIN 51758
个人防护装备dust mask type N95 (US), Eyeshields, Gloves
8.40130Sigma-Aldrich4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl(free radical) for synthesis627.87元/25 G;   1586.47元/100 G;   展开

产品说明

分析说明

Assay (GC, area%): ≥ 95.0 % (a/a)
Melting range (lower value): ≥ 67 °C
Melting range (upper value): ≤ 71 °C
Identity (IR): passes test

基本信息

经验(实验)分子式C9H18NO2
分子量172.24
MDL编号MFCD00006478
EC索引号218-760-9

产品性质

质量水平200
蒸汽压<0.01 hPa ( 20 ℃)
测定≥95.0% (GC)
自燃温度260 ℃ (DIN 51794)
效能1053 mg/kg LD50, oral (Rat)
pH值(酸碱度)8.2 (20 ℃, 20 g/L in H2O)
mp67-71 ℃
转变温度flash point 146 ℃ (DIN 51758)
溶解性 1670 g/L
储存温度2-30℃
InChI1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI keyUZFMOKQJFYMBGY-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07
警示用语:Danger
危险声明H302 - H318
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
危险分类Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)294.8 °F - DIN 51758
闪点(C)146 ℃ - DIN 51758
581500Sigma-AldrichTEMPOL-CAS 2226-96-2-CalbiochemA stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap.1288.09元/500 MG;   展开

产品说明

一般描述

A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.
A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

包装

500 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Free radical scavenger and nitric oxide spin trap

警告

Toxicity: Harmful (C)

重悬

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

其他说明

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H18NO2
分子量172.24
MDL编号MFCD00006478

产品性质

质量水平100
测定≥97% total nitrogen (N) basis
形式crystals
powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 orange
溶解性DMSO: 5 mg/mL
ethanol: soluble
water: soluble
运输ambient
储存温度−20℃
InChI1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChI keyUZFMOKQJFYMBGY-UHFFFAOYSA-N

安全信息

象形图GHS05GHS07
警示用语:Danger
危险声明H302 - H318
预防措施声明P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
危险分类Acute Tox. 4 Oral - Eye Dam. 1
储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)294.8 °F - DIN 51758
闪点(C)146 ℃ - DIN 51758
979179Amethyst4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy98%, 试剂级, 自由基48元/1G;   71元/5G;   153元/25G;   505元/100G;   展开

基本信息

分子式C9H18NO2
分子量172.25
沸点69-73
MDL编码MFCD00006478
Beilstein1422990
Merck14,9141
EINECS 编号218-760-9

安全信息

图形或危害标志
提示语Warning
危险说明H302
H315
H319
防范说明P280
P301+P312
P302+P352
P305+P351+P338
WGK1
RTECSTN8991000
TSCA
013608Fluorochem4-Hydroxy-2,2,6,6-tetramethyl piperidinyloxy free radical98%220元/5g;   220元/1g;   792元/25g;   1078元/100g;   展开

基本信息

CAS Number2226-96-2
MDL NumberMFCD00006478
Melting Point69-71℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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