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CAS: 22232-54-8
分子式: C7H10N2O2S
分子量: 186.23
熔点: 124 °C
中文名称: 
仲丁威
卡比马唑
甲亢平
新麦咔唑
3-甲基-2-硫代咪唑啉-1-羧酸乙酯
英文名称: 
3-methyl-2-thioxo-4-imidazoline-1-carboxylic aci ethyl ester
1h-imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo, ethyl ester
3-methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester
athyromazole
basolest
carbethoxymethimazole
carbimazol
carbimazole
cg1
neomercazole
tyrazol
2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester
O-ethyl S-(1-methylimida-zol-2-yl)carbamate
1-Ethoxycarbonyl-2,3-dihydro-3-
展开更多英文名
性质描述: 白色或类白色结晶性粉末。熔点122-125℃。在20℃时,该品可溶于500份水、50份乙醇、330份醚、3份氯仿、17份丙酮。有特臭,味苦。
生产方法: 由氯代乙醛缩二乙醇经胺化、环合、缩合而得。1.胺化将氯代乙醛缩二乙醇、甲胺、甲醇加入耐压锅中反应得2-甲氨基乙醛缩二乙醇。2.环合将2-甲氨基乙醛缩二乙醇与盐酸、硫氰酸钾一起加热,得1-甲基-2-巯基咪唑。3.缩合将1-甲基-2-巯基咪唑缩于吡啶中,滴加氯甲酸乙酯,得卡比马唑。
用途: 为抗甲状腺药,与他巴唑同属巯基咪唑类。卡比马唑是他巴唑的前体药体,在体内转化为他巴唑,其作用和不良反应都与他巴唑相似,作用较缓慢,维持时间比他巴唑长。用于甲状腺亢进。
推荐供应商
货号品牌产品名称规格包装、参考价格详情
C863994MACKLINCarbimazole98%27元/200mg;   60元/1g;   139元/5g;   456元/25g;   1823元/100g;   5340元/500g;   展开
储存:2-8℃,充氩保存
状态:白色到几乎白色粉末到晶体
C793639MACKLINCarbimazole10mM in DMSO428元/1ml;   展开
储存:-20°C
C1080TCICarbimazole>95.0%(HPLC)100元/1G;   395元/5G;   1690元/25G;   展开

基本信息

纯度/分析方法>95.0%(HPLC)
分子式/分子量C7H10N2O2S = 186.23
外观与形状(20℃)固体
储存在惰性气体下存放于惰性气体之中
应避免的情况空气
Reaxys-RN144339
PubChem物质ID87566113
SDBS (AIST Spectral DB)18400
Merck Index (14)1798
MDL编号MFCD00027421

技术规格

AppearanceWhite to Almost white powder to crystal
Purity(HPLC)min. 95.0 area%
Melting point122.0 to 125.0 ℃
Thiamazolemax. 0.5 w/w%

物性(参考值)

熔点124 ℃

相关法规

RTECS#NJ2441000
L08218Alfa AesarEthyl 3-methyl-2-thionoimidazoline-1-carboxylate97%1399元/5g;   5153元/25g;   13561元/100g;   展开

应用
Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.

备注
Light sensitive. Keep the container tightly closed in a dry and well-ventilated place.

基本信息

MDL
MFCD00027421

EINECS
244-854-4

分子式
C7H10N2O2S

分子量
186.24

熔点
122-126°

灵敏度
Light Sensitive. Ambient temperatures.

形态
Powder

溶解性
Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.

Beilstein
144339

Merck
14,1798

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H319-H317
Harmful if swallowed.Causes serious eye irritation.May cause an allergic skin reaction.

Precautionary Statements
P261-P280a-P305+P351+P338-P301+P312a-P321-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36-43
Harmful if swallowed.Irritating to eyes.May cause sensitization by skin contact.

安全等级
24-26-37-60
Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
NJ2441000

TSCA

PHR1684SupelcoCarbimazolePharmaceutical Secondary Standard; Certified Reference Material1880.17元/1 G;   展开

产品说明

一般描述

Carbimazole is an orally administered thioimidazole drug, which is indicated for the management of hyperthyroidism as well as Grave′s disease in humans. It is used to facilitate the growth of animals for human consumption.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Carbimazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA6300 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

基本信息

经验(实验)分子式C7H10N2O2S
分子量186.23
EC 号244-854-4

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 1 g
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur C0465000
储存温度2-8℃
InChI1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
InChI keyCFOYWRHIYXMDOT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
C0465000CarbimazoleEuropean Pharmacopoeia (EP) Reference Standard1277.32元/ ;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C7H10N2O2S
分子量186.23
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
InChI1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
InChI keyCFOYWRHIYXMDOT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
SML0931Sigma-AldrichCarbimazole≥98% (HPLC)689.87元/10 MG;   2255.27元/50 MG;   展开

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. Carbimazole is used to treat hyperthyroidism. Also, carbimazole induces phosphorylation of eukaryotic elongation factor eEF2.

基本信息

经验(实验)分子式C7H10N2O2S
分子量186.23
EC 号244-854-4
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 5 mg/mL, clear (warmed)
储存温度2-8℃
InChI1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
InChI keyCFOYWRHIYXMDOT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
BP749CarbimazoleBritish Pharmacopoeia (BP) Reference Standard1861.35元/100 MG;   展开

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

包装

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C7H10N2O2S
分子量186.23
EC 号244-854-4
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameBP
格式neat
储存温度2-8℃
InChI1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
InChI keyCFOYWRHIYXMDOT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
053981FluorochemCarbimazole98+%484元/250mg;   1122元/1g;   3784元/5g;   展开

基本信息

CAS Number22232-54-8
MDL NumberMFCD00027421
Melting Point124℃

安全信息

图形或危害标志
危险性说明 H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear .
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P333 + P313: If skin irritation or rash occurs: Get medical advice/attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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