| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 |
| C860607 | MACKLIN | 葫芦素 I | >98% | 7561元/5mg; | 展开 |
|
| 238590 | Sigma-Aldrich | Cucurbitacin I, Cucumis sativus L.-CAS 2222-07-3-Calbiochem | A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. | 3736.22元/1 MG; | 展开 |
产品说明 一般描述 A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that exhibits anti-proliferative and anti-tumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/Signal transducer and activator of transcription 3 (Jak/STAT3) signaling pathway. Reported to suppress STAT3 tyrosine phosphorylation in v-src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Also shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt1, ERK1/2, or JNK.
A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK. 包装 1 mg in Plastic ampoule
Packaged under inert gas 生化/生理作用 Cell permeable: yes
Primary Target
JAK/STAT3
Product does not compete with ATP.
Reversible: no
Target IC50: 500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells 警告 Toxicity: Standard Handling (A) 其他说明 Blaskovich, M.A., et al. 2003. Cancer Res.63, 1270. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C30H42O7 | | 分子量 | 514.65 |
产品性质 | 质量水平 | 100 | | 测定 | ≥95% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
protect from light | | 颜色 | white | | 溶解性 | ethanol: 10 mg/mL
DMSO: 100 mg/mL | | 运输 | ambient | | 储存温度 | −20℃ | | InChI | 1S/C30H42O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3/b12-11+/t17-,19-,20+,23+,27+,28-,29+,30+/m1/s1 | | InChI key | NISPVUDLMHQFRQ-MKIKIEMVSA-N |
安全信息 | 象形图 |  | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| C4493 | Sigma-Aldrich | Cucurbitacin I hydrate | ≥95% (HPLC), solid | 2975.64元/1 MG; | 展开 |
产品说明 包装 1 mg in glass bottle 生化/生理作用 葫芦素 I (JSI-124) 是一种新型的 JAK 激酶 2/信号转导子和转录激活子 3 (JAK2/STAT3) 信号通路选择性抑制剂，具有抗增殖和抗肿瘤属性。 特点和优势 该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
该化合物出现在《受体分类和信号转导手册》的 JAK 页。要浏览其他手册页， 单击此处 。 基本信息 | 经验(实验)分子式 | C30H42O7 · xH2O | | 分子量 | 514.65 (anhydrous basis) | | EC 号 | 218-736-8 | | PubChem化学物质编号 | 329775065 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥95% (HPLC) | | 形式 | solid | | 颜色 | white to off-white | | 溶解性 | DMSO: >5 mg/mL | | 储存温度 | −20℃ | | SMILES string | O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C | | InChI | 1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1 | | InChI key | ZKDSPEWKSJCXQE-NEBRQAMTSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H300 | | 预防措施声明 | P264 - P301 + P310 | | 危险分类 | Acute Tox. 1 Oral | | 储存分类代码 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|
| PHL89464 | | Cucurbitacin I | phyproof® Reference Substance | 6952.61元/10 MG; | 展开 |
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息 | 经验(实验)分子式 | C30H42O7 | | 分子量 | 514.65 | | NACRES | NA.24 |
产品性质 | 等级 | primary reference standard | | 产品线 | phyproof® Reference Substance | | 测定 | ≥98.0% (HPLC) | | manufacturer/tradename | PhytoLab | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | 2-8℃ | | InChI | 1S/C30H42O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3/b12-11+/t17-,19-,20+,23+,27+,28-,29+,30+/m1/s1 | | InChI key | NISPVUDLMHQFRQ-MKIKIEMVSA-N |
安全信息 | 象形图 | | | 警示用语： | Danger | | 危险声明 | H301 | | 预防措施声明 | P301 + P330 + P331 + P310 | | 危险分类 | Acute Tox. 3 Oral | | 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
m.cnreagent.com