CAS 22033-87-0; tro 19622

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CAS:

22033-87-0

分子式:

C₂₇H₄₅NO

分子量:

399.65

英文名称:

tro 19622

cholest-4-en-3-one, oxime

nsc 21311

olesoxime

用途:

Olesoxime (TRO 19622) 是一种靶向线粒体的神经保护性试剂，促进细胞存活，EC50 为 3.2±0.2 µM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

O880337

MACKLIN

Olesoxime

≥98%

492元/5mg; 1176元/25mg;

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储存：2-8℃

O792596

MACKLIN

Olesoxime

10mM in DMSO

329元/1ml;

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储存：-20°C

T3077

Sigma-Aldrich

TRO 19622

≥98% (HPLC), solid

1746.67元/5 MG; 6233.79元/25 MG;

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产品说明

应用

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons². TRO 19622 is also known to stimulate myelin repair in rat models of demyelination³.

包装

5, 25 mg in glass bottle

生化/生理作用

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain⁴.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).

制备说明

TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

基本信息

经验(实验)分子式	C₂₇H₄₅NO
分子量	399.65
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: >10 mg/mL
储存温度	−20℃
InChI	1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
InChI key	QNTASHOAVRSLMD-SGWCAAJKSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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