| CAS: | 220036-08-8 | ||
| 分子式: | C11H17N5O2 | ||
| 分子量: | 251.28 | ||
| 熔点: | 252.5-253.7 °C(lit.) | ||
| 英文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||
| N794696 | MACKLIN | NU6027 | 10mM in DMSO | 648元/1ml; | 展开 | ||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||
| 189299 | Sigma-Aldrich | ATR/CDK Inhibitor, NU6027-CAS 220036-08-8-Calbiochem | The ATR/CDK Inhibitor, NU6027, also referenced under CAS 220036-08-8, controls the biological activity of ATR/CDK. This small molecule/inhibitor is primarily used for Cancer applications. | 2671.25元/10 MG; | 展开 | ||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 µM for CDK1, and Ki = 1.3 µM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 µM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 µM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. 包装 10 mg in Glass bottle 警告 Toxicity: Standard Handling (A) 其他说明 Peasland, A., et al. 2011., Br J Cancer. 105, 372. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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