| CAS: | 219766-25-3 | ||
| 分子式: | C22H21N3O3S | ||
| 分子量: | 407.49 | ||
| 中文名称: |
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| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||||||||||||||||
| A792478 | MACKLIN | ANA-12 | 10mM in DMSO | 881元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||||||||||||||||
| A873754 | MACKLIN | ANA-12 | 98% | 456元/5mg; 1530元/25mg; 4590元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||
储存：2-8°C 状态：白色到米黄色粉末 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| 5.06304 | Sigma-Aldrich | TrkB Antagonist, ANA-12-CAS 219766-25-3-Calbiochem | 3162元/25 MG; | 咨询 | |||||||||||||||||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10 nM) exhibiting much reduced binding to the low affinity site (Kd =12 µM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice. 生化/生理作用 Primary Target 包装 Packaged under inert gas 警告 Toxicity: Standard Handling (A) 重悬 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 其他说明 Cazorla, M., et al. 2011. J. Clin. Invest.121,1846. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
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| SML0209 | Sigma-Aldrich | ANA-12 | ≥98% (HPLC) | 1666.25元/5 MG; 6711.52元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||||||||||||||||
产品说明 应用 ANA-12用于抑制原代小鼠皮层神经元和原代大鼠海马培养物中的TrkB。 包装 5, 25 mg in glass bottle 生化/生理作用 神经营养素脑源性神经营养因子(BDNF)及其受体原肌球蛋白相关激酶B(TrkB)已成为几种情绪障碍(包括焦虑症和抑郁症)的病理生理学的关键介体。ANA-12是一种TrkB配体，可有效阻止BDNF激活受体。 它选择性地与TrkB结合并抑制TrkB下游的过程，而不会改变TrkA和TrkC的功能。在成年小鼠中，ANA-12模型可降低大脑中TrkB的活性，而不会影响神经元的存活。给予 ANA-12 的小鼠在预测人类抗焦虑和抗抑郁特性的各种试验中显示焦虑和抑郁相关行为减少。ANA-12 可能是研究 BDNF/TrkB 信号的一种有价值的工具，并可能构成开发下一代治疗心境障碍药物的先导化合物。还有 N-T19，其效价较低。 基本信息
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