产品说明

一般描述

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
Hsp70
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

其他说明

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息

产品说明

应用

KNK437已用于:

• 作为热休克因子1(HSF1)抑制剂用于研究其对耐化学性小鼠细胞活力和凋亡激活的抑制作用
• 作为HSF1抑制剂用于研究其对结肠直肠癌细胞活力和凋亡的影响
• 作为热休克蛋白70(HSP70)抑制剂用于研究其对谷氨酰胺诱导的HSP70和炎症介质释放的影响

包装

5, 25 mg in glass bottle

生化/生理作用

KNK437 抑制热激蛋白(包括 hsp -27、-40、-70、-72 和 -105)的积累。 KNK437 比槲皮素更有效地抑制细胞的耐热性。
KNK437 是一种亚苄基内酰胺化合物。

基本信息

产品性质

安全信息