| CAS: | 217645-70-0 | |||
| 分子式: | C21H24ClFN4O3 | |||
| 分子量: | 434.89 | |||
| 英文名称: |
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| 用途: | BX471 (ZK-811752) 是以一种口服有效的，选择性，非多肽的 CCR1 拮抗剂，Ki 值为 1 nM，对其选择性是对 CCR2，CCR5 和 CXCR4 的 250 倍。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| B792597 | MACKLIN | BX471 | 10mM in DMSO | 856元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20°C, 干燥, 惰性气体 | |||||||||||||||||||||||||||||||||||||
| B880387 | MACKLIN | BX471 | ≥95% | 260元/10mg; 775元/50mg; 1379元/100mg; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20°C, 干燥, 惰性气体 状态：白色到棕褐色粉末 | |||||||||||||||||||||||||||||||||||||
| B6060 | TCI | BX 471 | >98.0%(HPLC) | 390元/5MG; 1450元/25MG; | 咨询 | ||||||||||||||||||||||||||||||||
基本信息
技术规格
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| SML0020 | Sigma-Aldrich | BX471 | ≥98% (HPLC) | 2062.13元/5 MG; 8219.59元/25 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 应用 BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration. It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT). 包装 5, 25 mg in glass bottle 生化/生理作用 BX471 blocks CCR1 and downregulates the mRNA expression of ICAM-1, P-selectin and E-selectin. It decreases the inflammatory responses in sepsis, prevents monocyte recruitment in inflammation sites in rheumatoid arthritis patients and inhibits interstitial leukocyte recruitment and fibrosis in mouse model of lupus nephritis. 特点和优势 This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. 基本信息
产品性质
安全信息
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