CAS 2172879-52-4; lit-927

CAS:

2172879-52-4

分子式:

C₁₇H₁₃ClN₂O₃

分子量:

328.75

英文名称:

lit-927

4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)-2(1h)-pyrimidinone

4-(4-chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1h)-one

用途:

LIT-927 是局部的、有口服活性的 CXC 趋化因子12 (CXCL12) 的中性配体，具有抗炎作用，对 CXCL12 结合到其受体 CXCR4 的 Ki 值为 267 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

L793980

MACKLIN

LIT-927

10mM in DMSO

930元/1ml;

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储存：-20°C

L880390

MACKLIN

LIT-927

98%

690元/5mg; 1050元/10mg; 2500元/50mg;

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储存：2-8℃
状态：黄色到橙色到棕色粉末

SML2893

Sigma-Aldrich

LIT-927

≥98% (HPLC)

833.87元/5 MG; 3365.56元/25 MG;

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产品说明

生化/生理作用

LIT-927 is an orally active CXCL12 (SDF1) neutraligand (K_d = 267) that selectively neutralizes CXCL12, but not CCL17, CCL22, CCL5, or CCL2 activity in cultures (10 μM LIT-927 against 5 nM chemokine-induced calcium mobilization). LIT-927 reduces eosinophil recruitment in a murine allergic airway hypereosinophilia model in vivo (330 nmol/kg intranasal, 350 nmol/kg ip. or 1400 μmol/kg po.), offering greatly improved oral activity and solubility than Chalcone-4, and exhibiting little side-effects when compared with dexamethasone or CXCR4 antagonist AMD3100.

基本信息

经验(实验)分子式	C₁₇H₁₃ClN₂O₃
分子量	328.75
MDL编号	MFCD31726172

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow to brown
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	O=C1N=C(C=C(N1)C2=CC=C(C(OC)=C2)O)C3=CC=C(C=C3)Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable