CAS 217094-32-1; k-604

CAS:

217094-32-1

分子式:

C₂₃H₃₂Cl₂N₆OS₃

分子量:

575.64

英文名称:

k-604

4-[2-(1h-benzimidazol-2-ylthio)ethyl]-n-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride

2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1yl]-n-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide dihydrochloride

k604

用途:

K-604 dihydrochloride 是一种有效的选择性酰基辅酶 A：胆固醇酰基转移酶 1 (ACAT-1) 抑制剂，IC50 为 0.45±0.06 μM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

K880401

MACKLIN

K-604 dihydrochloride

≥99%

199元/1mg; 588元/5mg; 1145元/10mg; 2788元/25mg;

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储存：2-8℃

SML1837

Sigma-Aldrich

K-604

≥98% (HPLC)

1758.39元/5 MG; 7096.85元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

K-604 inhibits against acyl-coenzyme A (acyl-CoA):cholesterol O-acyltransferase-1 (ACAT1, SOAT1) activitiy in a selective (IC₅₀ = 450 nM vs. 102.85 μ M against human ACAT1 and ACAT2, respectively) and acyl-CoA-competitive (Ki = 378 nM against oleoyl-coA) manner. K-604 inhibits cholesterol esterification in human monocyte-derived macrophages (IC₅₀ = 68.0 nM) and enhances cholesterol efflux from THP-1 macrophages in response to HDL3 or apolipoprotein A-I. Oral administration is efficacious against macrophage foam cell formation and atherosclerosis progression among F1B hamsters on a high-fat diet (1-10 mg/kg/day) and apoE-knockout mice (60 mg/kg/day) without affecting plasma cholesterol levels. K-604 is also reported to stimulate autophagy-mediated P301L-Tau degradation in cortical neurons from 3XTg-AD mice (500 nM).

基本信息

经验(实验)分子式	C₂₃H₃₀N₆OS₃ · 2HCl
分子量	575.64

产品性质

质量水平	100
测定	≥98% (HPLC)
储存条件	desiccated
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(NC1=C(SC)C=C(C)N=C1SC)CN2CCN(CCSC3=NC4=CC=CC=C4N3)CC2.[H]Cl.[H]Cl

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable