| CAS: | 2165340-32-7 | |||
| 分子式: | C17H15NO2 | |||
| 分子量: | 265.31 | |||
| 英文名称: |
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| 用途: | CU-CPT-9a 是 TLR8 的特异性拮抗剂，其 IC50 值为 0.5 nM。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||
| C880410 | MACKLIN | CU-CPT-9a | ≥99% | 820元/5mg; 1320元/10mg; 3730元/50mg; | 展开 | ||||||||||||||||||||||||||||
储存：2-8℃ | |||||||||||||||||||||||||||||||||
| C797650 | MACKLIN | CU-CPT-9a | 10mM in DMSO | 270元/1ml; | 展开 | ||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||
| SML2221 | Sigma-Aldrich | CU-CPT9a | ≥98% (HPLC) | 1311.9元/5 MG; 4232.97元/25 MG; | 展开 | ||||||||||||||||||||||||||||
产品说明 生化/生理作用 CU-CPT9a is a potent and selective inhibitor of Toll-like receptor 8 (TLR8). It binds to TLR8 at a site different from current small-molecule TLR7/8 agonists, stabilizing the TLR8 dimer in its resting state, thus preventing TLR8 activation It exhibited an IC50 value of 0.5 nM and blocked TLR8 activation induced by either resiquimod (R848) or ssRNA without affecting the closely related TLR7 or cells expressing other TLRs. CU-CPT9a also suppressed TNF-α levels in a dose-dependent manner in cells from patients with rheumatoid arthritis. 基本信息
产品性质
安全信息
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