CAS 215923-54-9; cx546

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CAS:

215923-54-9

分子式:

C₁₄H₁₇NO₃

分子量:

247.29

英文名称:

cx546

1-(1,4-benzodioxan-6-ylcarbonyl)piperidine

用途:

CX546是AMPAR受体选择性激动剂。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

C880418

MACKLIN

CX546

98%

183元/10mg; 690元/50mg; 1104元/100mg;

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储存：2-8℃

C271

Sigma-Aldrich

CX546

≥98% (HPLC), solid

3347.59元/10 MG; 11465.2元/50 MG;

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产品说明

一般描述

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

应用

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

包装

10, 50 mg in glass bottle

生化/生理作用

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
Positive AMPA glutamate receptor modulator.

注意

Photosensitive

基本信息

经验(实验)分子式	C₁₄H₁₇NO₃
分子量	247.29
MDL编号	MFCD01860868
PubChem化学物质编号	24277960
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	protect from light
颜色	white to off-white
溶解性	DMSO: ≥10 mg/mL
储存温度	2-8℃
SMILES string	O=C(N1CCCCC1)c2ccc3OCCOc3c2
InChI	1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
InChI key	LJUNPHMOGNFFOS-UHFFFAOYSA-N
Gene Information	human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

433006

Fluorochem

(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone

95%

6182元/250mg; 15444元/1g;

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基本信息

CAS Number	215923-54-9
MDL Number	MFCD01860868

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