CAS 215543-92-3; 3-[4-甲基-2-(2-氧代-1,2-二氢-吲哚-3-亚甲基)-1h-吡咯-3-基]-丙酸; su-5402

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货号

品牌

产品名称

规格

包装、参考价格

详情

S872615

MACKLIN

SU5402

99%

518元/5mg; 1972元/25mg;

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储存：-20℃
状态：浅黄色到暗橙色粉末

S794939

MACKLIN

SU5402

10mM in DMSO

519元/1ml;

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储存：-20°C

572630

Sigma-Aldrich

SU5402-CAS 215543-92-3-Calbiochem

SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).

3352.28元/500 μG; 5901.43元/1 MG; 8082.94元/2 MG;

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产品说明

一般描述

A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC₅₀ = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC₅₀ = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.

包装

500 μg in Plastic ampoule
1 mg in Plastic ampoule
2 mg in Glass bottle

生化/生理作用

Reversible: yes
Cell permeable: yes
Primary Target
Fibroblast growth factor receptor 1 (FGFR1)
Product competes with ATP.
Target IC₅₀: 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Mohammadi, M., et al. 1997. Science 276, 955.

法律信息

Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₁₆N₂O₃
分子量	296.32
MDL编号	MFCD08235144

产品性质

质量水平	200
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
溶解性	DMSO: 25 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable

SML0443

Sigma-Aldrich

SU-5402

≥98% (HPLC)

1476.5元/5 MG; 5967.61元/25 MG;

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产品说明

应用

SU5402 已被用作成纤维细胞生长因子受体抑制剂：

在细胞信号传导实验中刺激细胞，用于 MTT(3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐)试验
，以研究其对成骨标记物表达以及骨保护素和 RANKL(runt 相关转录因子 (RUNX)-2
)表达的影响，以制备细胞培养基用 DMSO(二甲基超氧化物)的储备液，并对胚胎进行共处理
，以研究其对成骨标记物的影响。

包装

5, 25 mg in glass bottle

生化/生理作用

SU-5402 是一种 FGFR 拮抗剂和血管生成抑制剂。
SU-5402 对酪氨酸激酶的活动具有抑制作用。与成纤维细胞生长因子受体 (FGFR) 上的 ATP 结合站点竞争性结合。

特点和优势

该化合物是激酶磷酸酶生物学研究的特色产品。点击此处，发现更多特色激酶磷酸酶生物学产品。前往 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

基本信息

经验(实验)分子式	C₁₇H₁₆N₂O₃
分子量	296.32
MDL编号	MFCD08235144
PubChem化学物质编号	329824725
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	light yellow to dark orange
溶解性	DMSO: 10 mg/mL (clear solution)
储存温度	−20℃
SMILES string	Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
InChI	1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key	JNDVEAXZWJIOKB-JYRVWZFOSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

440271

Fluorochem

2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

>95%

3960元/1mg;

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基本信息

CAS Number	215543-92-3
MDL Number	MFCD08235144