CAS 214358-33-5; 1400w 二盐酸盐; 1400w dihydrochloride

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品牌

产品名称

规格

包装、参考价格

N872498

MACKLIN

1400W 2HCl

99%

218元/5mg; 538元/25mg; 1680元/100mg; 4000元/250mg;

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储存：-20℃
状态：白色固体

N766771

MACKLIN

1400W 2HCl

10mM in DMSO

418元/1ml;

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储存：-20℃

100050

Sigma-Aldrich

1400W-CAS 214358-33-5-Calbiochem

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM).

2340.22元/5 MG;

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产品说明

一般描述

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
A selective, irreversible, slow, tight binding inhibitor of inducible nitric oxide synthase (iNOS, K_d = 7 nM) both in vitro and in vivo. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
iNOS
Product does not compete with ATP.
Reversible: no
Kd = 7 nM against inducible nitric oxide synthase (iNOS)

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.

其他说明

Parmentier, S., et al. 1999. Br. J. Pharmacol.127, 546.
Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₀H₁₅N₃ · 2HCl
分子量	250.17
MDL编号	MFCD03428622

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	water: 1 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C10H16N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5,13H,6-7,11-12H2,1H3/q+1/p+1
InChI key	FFSSUWWXUDLVQZ-UHFFFAOYSA-O

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

W4262

Sigma-Aldrich

1400W dihydrochloride

>98%, solid

1972.87元/10 MG;

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产品说明

应用

使用1400W二氢氯化物：

用作诱导型一氧化氮的强抑制剂，分析其对大鼠肠缺血再灌注(I/R)损伤模型的影响
用作诱导型一氧化氮合酶(iNOS)选择性抑制剂，说明PM10诱导型内皮功能障碍的机制
研究其对大鼠肾缺血/再灌注损伤的疗效
作为iNOS抑制剂，研究其在低压缺氧复氧后中和空间记忆障碍的能力

包装

10 mg in glass bottle

生化/生理作用

1400W 二盐酸盐是诱导型一氧化氮合酶(iNOS)的有效选择性抑制剂。

特点和优势

该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
该化合物出现在受体分类和信号转导手册的一氧化氮合酶页，点击此处。

基本信息

经验(实验)分子式	C₁₀H₁₅N₃· 2 HCl
分子量	250.17
MDL编号	MFCD03428622
PubChem化学物质编号	24278778
NACRES	NA.77

产品性质

质量水平	100
测定	>98%
形式	solid
储存条件	desiccated
创始人	GlaxoSmithKline
运输	wet ice
储存温度	−20℃
SMILES string	Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI	1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key	WDJHSQZCZGPGAA-UHFFFAOYSA-N
Gene Information	human ... NOS1(4842), NOS2(4843), NOS3(4846)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

M02676

Fluorochem

N-(3-Aminomethyl)benzylacetamidine

4928元/5mg;

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基本信息

CAS Number	214358-33-5
MDL Number	MFCD03428622
Melting Point	215-220℃

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .