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CAS: 2142-68-9
分子式: C8H7ClO
分子量: 154.59
沸点: 228-229℃
熔点: 52-56C
中文名称: 
邻氯苯乙胴
2'-氯苯乙酮
2'-氯苯基乙酮
邻氯苯乙酮
英文名称: 
1-(2-chloro-phenyl)-ethanone
Acetophenone,2'-chloro-
o-Chloroacetophenone
2'-chloro-acetophenon
2'-chloroacetophenone
1-(2-chlorophenyl)-ethanon
o-chloroacetophonone
1-(2-Chlorophenyl)ethanone
o-Chlorophenylmethyl ketone
性质描述: 无色油状液体。沸点113℃(2.4kPa),相对密度1.188,折射率1.5438,闪点83℃。微溶或难溶于水中,可溶解在乙醚中。
生产方法: 1.邻硝基乙苯法。2.邻氯苯甲酰氯法向反应器中先加入二氯甲烷,其中悬浮固体无水三氯化铝。再加入烷基铝卤化物(CH3)1.5AlCl1.5。当二氯甲烷开始回流时,迅速加入邻氯苯甲酰氯,添加后,继续搅拌1h。然后将反应混合物注入水中。此时因放热引起分解反应而使二氯甲烷沸腾。经蒸馏处理得产品。邻氯苯甲酰氯用量0.3mol,(CH3)1.5AlCl1.5 0.21mol,三氯化铝用量0.1mol;对1g邻氯苯甲酰氯采用1g-10g二氯甲烷。反应温度约40℃,产品收率98%。
用途: 本品用于合成支气管扩张药盐酸氯丙那林(氯喘)及其他精细化学品等。
推荐供应商
货号品牌产品名称规格包装、参考价格
C804535MACKLIN邻氯苯乙酮98%27元/5g;   34元/25g;   109元/100g;   421元/500g;   咨询
储存:2~8°C
状态:无色到黄色液体
折射率:n20/D 1.544
C1084TCI2'-Chloroacetophenone>97.0%(GC)275元/25G;   1855元/250G;   咨询

基本信息

纯度/分析方法>97.0%(GC)
分子式/分子量C8H7ClO = 154.59
外观与形状(20℃)液体
Reaxys-RN1858916
PubChem物质ID87566117
SDBS (AIST Spectral DB)15172
MDL编号MFCD00000560

技术规格

AppearanceColorless to Light orange to Yellow clear liquid
Purity(GC)min. 97.0 %

物性(参考值)

沸点229 ℃
闪点92 ℃
比重1.19
折射率1.55

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
H227 : 可燃液体。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P210 : 远离热源/火花/明火/热表面。禁止吸烟。
P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P370 + P378 : 火灾时:使用干砂、干粉或抗醇泡沫灭火。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。
P403 + P235 : 存放在通风良好的地方。保持低温。

相关法规

RTECS#AM6310000

运输信息

UN编号UN3416
类别6.1
包装类别 II
监管条件代码(*)
227337J&K2'-Chloroacetophenone97%95元/25G;   236元/100G;   520元/250G;   咨询

基本信息

分子式C8H7ClO
分子量154.59
沸点227-230
闪点92
密度1.190
MDL编码MFCD00000560
Beilstein1858916
EINECS 编号218-397-6

安全信息

图形或危害标志
提示语Warning
危险说明H302
H319
H335
防范说明P261
P305+P351+P338
UN号码3416
危险分类6.1
包装等级II
WGK3
RTECSAM6310000
A15232Alfa Aesar2'-Chloroacetophenone98%1263元/50g;   3187元/250g;   10965元/1000g;   咨询

基本信息

MDL
MFCD00000560

EINECS
218-397-6

分子式
C8H7ClO

分子量
154.60

沸点
228-229°

闪点
88°(190°F)

密度
1.189

折射率
1.5435

形态
Liquid

Beilstein
1858916

GHS危害和防范说明

GHS符号

Hazard Statements
H227-H301-H315-H319-H335
Combustible liquid.Toxic if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210e-P261-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Avoid breathing dust/fume/gas/mist/vapours/spray.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
AM6310000

TSCA

C17977Alfa Aesar2'-Chloroacetophenone97%1113元/25g;   3289元/100g;   咨询

基本信息

Ref#
17977

MDL
560

分子式
C8 H7 Cl O

分子量
154.6

闪点
88

密度
1188

形态
Clear colourless to pale yellow liquid

安全信息

危险等级
6.1

包装组
II

183709Sigma-Aldrich2′-Chloroacetophenone97%462.9元/25 G;   920.46元/100 G;   咨询

产品说明

一般描述

2′-Chloroacetophenone undergoes stereoselective reduction to (R)-2′-chloro-1-phenyl-ethanol by Saccharomyces cerevisiae B5. It is commonly used as lacrimator.

应用

2′-Chloroacetophenone was employed as model substrate to investigate the enzymatic performance of Aspergillus terreus and Rhizopus oryzae in enantioselective bioreductions using glycerol as a co-solvent.

包装

25, 100 g in glass bottle

基本信息

线性分子式ClC6H4COCH3
分子量154.59
Beilstein1858916
EC 号218-397-6
MDL编号MFCD00000560
PubChem化学物质编号24851071
NACRESNA.22

产品性质

质量水平100
测定97%
形式liquid
bp227-230 ℃
密度1.190 g/mL at 20 ℃
SMILES stringCC(=O)c1ccccc1Cl
InChI1S/C8H7ClO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,1H3
InChI keyZDOYHCIRUPHUHN-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)190.4 °F
闪点(C)88 ℃
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
8.41072Sigma-Aldrich2′-Chloroacetophenonefor synthesis715.78元/50 ML;   咨询

产品说明

分析说明

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.188 - 1.192
Identity (IR): passes test

基本信息

经验(实验)分子式C8H7ClO
分子量154.59
MDL编号MFCD00000560
EC索引号218-397-6

产品性质

质量水平200
测定≥98.0% (GC)
效能1820 mg/kg LD50, oral (Rat)
转变温度flash point 88 ℃
密度1.189 g/cm3 at 20 ℃
储存温度2-30℃
InChI1S/C8H7ClO/c1-6(10)7-4-2-3-5-8(7)9/h2-5H,1H3
InChI keyZDOYHCIRUPHUHN-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)190.4 °F
闪点(C)88 ℃
IRT-002SAccuStandard2'-Chloroacetophenone,100 μg/mL in Hexane100 μg/mL in Hexane309元/1mL;   咨询
2'-Chloroacetophenone2'-氯苯乙酮2142-68-9100 µg/mL
003397Fluorochem2'-Chloroacetophenone95%220元/1g;   264元/25g;   484元/50g;   880元/100g;   1452元/250g;   咨询

基本信息

CAS Number2142-68-9
MDL NumberMFCD00000560
Boiling Point228-229℃
Density1.188

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H311: Toxic in contact with skin.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H331: Toxic if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P311: Call a POISON CENTER or doctor/physician.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P322: Specific measures (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P361: Remove/Take off immediately all contaminated clothing.
P362: Take off contaminated clothing and wash before reuse.
P363: Wash contaminated clothing before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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