CAS 2103278-86-8; sars-cov-2 main protease inhibitor 11a

CAS:

2103278-86-8

分子式:

C₂₅H₃₂N₄O₄

分子量:

452.55

英文名称:

sars-cov-2 main protease inhibitor 11a

sars-cov-2 mpro inhibitor 11a

n-((S)-3-cyclohexyl-1-oxo-1-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-ylamino)propan-2-yl)-1h-indole-2-carboxamide

sars-cov-2 3clpro inhibitor 11a

n-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-1h-indole-2-carboxamide

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

B742357

MACKLIN

Bofutrelvir

98%

1410元/1mg; 4490元/5mg;

储存：-20°C
状态：固体

SML2877

Sigma-Aldrich

SARS-CoV-2 main protease inhibitor 11a

≥90% (HPLC)

1468.82元/5 MG; 5921.53元/25 MG;

产品说明

生化/生理作用

Inhibitor 11a is a COVID-19 corona virus SARS-CoV-2 inhibitor that covalently targets the main protease (Mpro; a.k.a. 3C-like protease or 3CLpro) substrate site Cys145 (IC50 = 53 nM; 10 min pre-incubation with 30 nM SARS-CoV-2 Mpro prior to the addition of 20 μM substrate). Inhibitor 11a effectively inhibits SARS-CoV-2 replication in Vero E6 cultures (IC50 = 0.53 μM 24 h post infection with MOI = 0.05; cytotoxicity CC50 >100 μM) with good pharmacokinetic properties in mice in vivo (5 mg/kg via i.p. or i.v.).

基本信息

经验(实验)分子式	C₂₅H₃₂N₄O₄
分子量	452.55

产品性质

质量水平	100
测定	≥90% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(N[C@@H](CC1CCCCC1)C(N[C@@H](C[C@H]2C(NCC2)=O)C=O)=O)C3=CC4=CC=CC=C4N3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable