基本信息

技术规格

Technical Notes:

1. Biaryl bisphosphine ligand with narrow dihedral angle. The DTBM SEGPHOS® ligand, as the

ruthenium complex, gives superior enantioselectivity and diaste reoselectivity through dynamic kinetic resolution in the asymmetric hydrogenation of a-substituted-ß-ketoesters useful in the synthesis of carbapenum antibiotics.

2. With rhodium, preferential enantioselective hydrogenation of more reactive olefin of extended enone structure .

3.Rhodium catalyzed chemo-, regio, and entantioselective 2 + 2 + 2 cycloaddition of alkynes with isocyanates .

4.With copper, enantioselective cross Aldol-type reaction of acetonitrile.4

5.With copper, enantioselective vinylsilane alkenylation of aldehydes .5

6.Gold carbene mediated stereoselective cyclopropanation of propargyl esters.

7.With copper, enantioselective 1,2 -reduction of ketones, and 1 ,4-reduction of a a,ß-usaturatedesters.

8.With copper, catalytic enantioselective Mannich-type reaction.

9.Enantioselective fluorination of b ß-keto esters, tert- butoxycarbonyl lactones and lactmes with Sodeoka's Pd-aqua complex and a fluorinating reagent.

10.Rh-catalyzed intramolecular olefin or carbonyl hydroacylation. 10

11.Pd-catalyzed y-arylation of ß,y-unsaturated ketones.

12Involved in numerous conjugate alkynylation, and ring-opening alkynylation of

azabenzonorbornadienes.

13.Involved in asymmetric hydroamination of bicyclic alkenes/die nes, 13a diamination of conjugated dienes,sb and hydroalkoxylation/hydrosulfenylation of allenes.se

14.Used in cycloaddition reactions such as 1,3-dipolar cycloaddition of azomethine ylides, and Au-catalyzed 2 +2 cycoaddition of allenes.

15.Asymmetric conjugate addition of nitroalkanes to a,ß-usaturated thioamides.

16.Asymmetric synthesis of isothiazoles through Cu catalyzed conjugate addition of allyl cyanide to a,ß-usaturated thioamides .

17.Asymmetric Ag-catalyzed cycloadditions."

18.Rhodium-catalyzed c c bond cleavage to generate acyclic, asymmetric quaternary centers.

19.Iridium-catalyzed intermolecular hydroamidation of olefins .

20.Iridium-catalyzed intermolecular hydroamidation of olefins.

21.CuH-catalyzed asymmetric hydroamination of olefins.

产品说明

应用

作为以下反应的催化配体：

• 通过α,β-不饱和酮的对映选择性还原反应，对映选择性合成仲烯丙醇
• 通过铑催化的烯丙基或丙二烯环丁醇的重排，立体选择性制备环己酮衍生物
• 铜催化的β-取代不饱和膦酸酯的不对称共轭还原，得到光学活性的β-立体异构烷基膦酸酯
• 通过对映选择性C-C键活化和丙二烯环丁醇的扩环反应实现Rh催化的去对称化反应，从而不对称合成环己烯酮
• 通过Rh催化的[2+2+2]环加成反应，实现P-立体异构炔基氧化膦的对映选择性合成及晶体结构分析

包装

1 g in glass bottle
50, 100 mg in glass insert

法律信息

与 Takasago 联合销售，仅供研究之用。日本注册号3148136
SEGPHOS is a registered trademark of Takasago Intl. Corp.

基本信息

产品性质

安全信息