CAS 2100284-59-9; az3451

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CAS:

2100284-59-9

分子式:

C₃₀H₂₇BrN₄O₃

分子量:

571.46

英文名称:

az3451

2-(6-bromo-1,3-benzodioxol-5-yl)-n-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1h-benzimidazole-5-carboxamide

用途:

AZ3451 是蛋白酶激活受体-2 (protease-activated receptor-2 (PAR2)) 拮抗剂，IC50 值为 23 nM。

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货号

品牌

产品名称

规格

包装、参考价格

详情

A880537

MACKLIN

AZ3451

≥99%

441元/5mg; 773元/10mg;

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储存：2-8℃

A792601

MACKLIN

AZ3451

10mM in DMSO

648元/1ml;

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储存：-20°C

SML2050

Sigma-Aldrich

AZ3451

≥98% (HPLC)

1225.94元/5 MG; 4776.54元/25 MG;

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产品说明

应用

AZ3451 has been used as a protease-activated receptor 2 (PAR-2) antagonist to study the involvement of PAR-2 receptors in factor X activated (FXa)-induced upregulation of the cell adhesion molecules.

生化/生理作用

AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2), a G protein-coupled receptor thought to be involved in inflammatory diseases, pain, allergic associated diseases (eosinophil migration, mast cells) and cancers. AZ3451 was found to bind to a remote allosteric site outside the helical bundle that is different from the site previously found on PAR1, and had an IC50 value of 23 nM. AZ3451 was able to completely inhibit ERK phosphorylation when added to 1321N1 cells overexpressing wild-type human PAR2.
AZ3451 exhibits anti-inflammatory function in vivo. It can be used as a potential therapeutic for osteoarthritis (OA).

基本信息

经验(实验)分子式	C₃₀H₂₇BrN₄O₃
分子量	571.46
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	N#CC1=CC=C(NC(C2=CC=C(N([C@H](C3CCCCC3)C)C(C4=CC(OCO5)=C5C=C4Br)=N6)C6=C2)=O)C=C1

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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