CAS 2099142-76-2; bay-850 trihydrochloride

CAS:

2099142-76-2

分子式:

C₃₈H₄₄ClN₅O₃

分子量:

654.252

英文名称:

bay-850 trihydrochloride

n-((R)-1-((1S,4S)-4-aminocyclohexylamino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5-(((R)-1-p-tolylethylamino)methyl)furan-2-yl)benzamide trihydrochloride

n-[(2R)-1-[(4-aminocyclohexyl)amino]-3-(4-cyanophenyl)propan-2-yl]-2-chloro-4-methoxy-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide trihydrochloride

用途:

BAY-850 是三磷酸腺苷酶家族蛋白 2 (ATAD2) 的选择性有效抑制剂，其 IC50 值为 166 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

B910565

MACKLIN

BAY-850

98%

8510元/10mg;

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储存：-20°C，密闭，干燥
状态：白色到灰白色到米黄色粉末

SML2748

Sigma-Aldrich

BAY-850 trihydrochloride

≥98% (HPLC)

2521.28元/5 MG; 10119.8元/25 MG;

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产品说明

生化/生理作用

BAY-850 is a chemical probe that targets ATPase family AAA domain-containing protein 2 (ATAD2) bromodomain (BD) with submicromolar affinity (K_d of 84.9 nM by MST and 120 nM by BROMOscan) and high selectivity over all other bromodomains tested (no BROMOscan hits at 10 μM). BAY-850 blocks ATAD2 BD from binding acetylated H4 peptide in cell-free assays (IC₅₀ of 20 nM) and displaces full-length ATAD2 from chromatin in live cells (effctive conc. 1 μM by HTRF). To avoid potential unspecific off-target effects, concentrations above 5 μM are not recommended. BAY-460 is a companion control compound with strongly reduced ATAD2 inhibitory potency (IC₅₀ = 16 μM by cell-based HTRF assay; no activity at 10 μM by BROMOscan).

基本信息

经验(实验)分子式	C₃₈H₄₄ClN₅O₃ · 3HCl
分子量	763.62

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	H₂O: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3