CAS 2097971-11-2; (s,r,s)-ahpc-peg3-nh2 hydrochloride

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CAS:

2097971-11-2

分子式:

C₃₀H₄₆ClN₅O₇S

分子量:

656.23

英文名称:

(s,r,s)-ahpc-peg₃-nh₂ hydrochloride

(2s,4r)-1-((s)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

用途:

(S,R,S)-AHPC-PEG3-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 3 个单元 PEG linker。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S880552

MACKLIN

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

≥99%

655元/10mg; 1309元/25mg;

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储存：2-8℃
状态：浅黄色到棕色固体

901511

Sigma-Aldrich

(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

≥95%

6332.19元/50 MG;

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产品说明

应用

Protein degrader builiding block (S,R,S)-AHPC-PEG₃-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation

Targeted Protein Degradation by Small Molecules

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₀H₄₅N₅O₇S · xHCl
分子量	619.77 (free base basis)
NACRES	NA.22

产品性质

质量水平	100
测定	≥95%
形式	powder or crystals
储存温度	2-8℃
SMILES string	O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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