| CAS: | 205989-12-4 | |
| 分子式: | C18H11N3O | |
| 分子量: | 285.3 | |
| 中文名称: |
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| 英文名称: |
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| 用途: | Luotonin A is a natural alkaloid, and binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death. |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | 详情 | ||||||||||||||||||||||||||||||||||||||||
| L912060 | MACKLIN | Luotonin A | 98% | 3500元/5mg; | 展开 | ||||||||||||||||||||||||||||||||||||||||
储存：-20°C，密闭，干燥 状态：白色到黄色固体 | |||||||||||||||||||||||||||||||||||||||||||||
| L4045 | Sigma-Aldrich | Luotonin A | ≥98% (HPLC) | 1675.23元/10 MG; 6682.83元/50 MG; | 展开 | ||||||||||||||||||||||||||||||||||||||||
产品说明 包装 10 mg in glass bottle 生化/生理作用 Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plant Paganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC50 1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC50 5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization. 重悬 Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported. 基本信息
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