| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |
| P964067 | MACKLIN | 小白菊内酯 | 97% | 300元/100mg; 450元/250mg; 1123元/1g; | 咨询 |
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| P797038 | MACKLIN | 小白菊内酯 | 10mM in DMSO | 648元/1ml; | 咨询 |
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| P816677 | MACKLIN | 小白菊内酯 | 分析标准品,≥98% | 988元/20mg; | 咨询 |
储存：2~8°C,易燃物区域 状态：白色或浅黄色粉末 |
| P1982 | TCI | Parthenolide | >97.0%(HPLC) | 290元/25MG; 990元/100MG; | 咨询 |
基本信息 | 纯度/分析方法 | >97.0%(HPLC) | | 分子式/分子量 | C15H20O3 = 248.32 | | 外观与形状(20℃) | 固体 | | 储存温度 | 0-10℃ | | 应避免的情况 | 加热 | | Reaxys-RN | 17582 | | PubChem物质ID | 135727274 | | Merck Index (14) | 7048 | | MDL编号 | MFCD00134592 |
技术规格 | Appearance | White to Light yellow powder to crystal | | Purity(HPLC) | min. 97.0 area% | | Specific rotation [a]20/D | -81.0 to -86.0 deg(C=1, CHCl3) |
物性(参考值) | 熔点 | 115 ℃ | | 比旋光度 [α]D | -84° (C=1,CHCl3) | | 溶解性(可溶于) | 氯仿 |
相关法规 |
| 552337 | J&K | Parthenolide | 98%, 来源于小白菊花 | 941元/100MG; 1986元/250MG; | 咨询 |
基本信息 | 分子式 | C15H20O3 | | 分子量 | 248.30 | | 熔点 | 115-116 | | MDL编码 | MFCD00134592 | | 存储条件 | Store at 2-8℃ |
安全信息 | 防范说明 | P262 | | WGK | 3 | | RTECS | LY4220000 |
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| C46215 | Alfa Aesar | Parthenolide | | 2138元/100mg; 9071元/500mg; | 咨询 |
基本信息 Ref#
46215 分子式
C15H20O3 分子量
296.94 GHS危害和防范说明 GHS符号
 Hazard Statements
H317
May cause an allergic skin reaction. Precautionary Statements
P280 P302+P352 P333+P313 |
| P0667 | Sigma-Aldrich | Parthenolide | ≥98% (HPLC) | 761.5元/5 MG; 2636.35元/25 MG; | 咨询 |
产品说明 应用 小白菊內酯已用于：
- 与vasohibin 1(血管生成抑制蛋白)结合形成晶体，以便研究微管蛋白脱酪氨酸化抑制机制
- 作为核因子活化B细胞(NF-κB)κ-轻链增强子的抑制剂，以及信号转导和转录活化因子(STAT)的抑制剂，研究其对CD36结合恶性疟原虫感染红细胞(IECD36)的细胞粘附的影响
- 作为亲脂试剂，研究其对外周血来源的CD8+T细胞生产白介素13和干扰素γ的影响
包装 5 mg in glass insert
25 mg in glass bottle 生化/生理作用 小白菊內酯(Parthenolide)是一种倍半萜内酯，丰富存在于小白菊叶和花中。小白菊內酯具有抗癌特性，可用于治疗侵袭性癌症。小白菊內酯也可用来治疗炎症和偏头痛。它可在信号转导和转录活化因子(STAT)抑制介导的促凋亡基因转录抑制中起作用。
抑制 NF-κB 活化的抗炎剂。 其他说明 野甘菊 ( Tanacetum parthenium ) 和其他植物中发现的倍半萜内酯。 基本信息 | 经验(实验)分子式 | C15H20O3 | | 分子量 | 248.32 | | MDL编号 | MFCD00134592 | | PubChem化学物质编号 | 24278621 | | NACRES | NA.77 |
产品性质 | 质量水平 | 100 | | 测定 | ≥98% (HPLC) | | mp | 115-116 ℃ (lit.) | | 储存温度 | 2-8℃ | | SMILES string | C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H] | | InChI | 1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1 | | InChI key | KTEXNACQROZXEV-ZRPLFPEYSA-N | | Gene Information | human ... ELA2(1991), IKBKG(8517), NFKB1(4790), NKAP(79576), NKRF(55922) |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H317 | | 预防措施声明 | P280 - P302 + P352 | | 危险分类 | Skin Sens. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| 512732 | Sigma-Aldrich | Parthenolide, Tanacetum parthenium-CAS 20554-84-1-Calbiochem | A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. | 1364.79元/50 MG; | 咨询 |
产品说明 一般描述 A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase. 包装 50 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes
Primary Target
the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Product does not compete with ATP.
Reversible: no 警告 Toxicity: Harmful & Carcinogenic / Teratogenic (E) 其他说明 Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息 | 经验(实验)分子式 | C15H20O3 | | 分子量 | 248.32 | | MDL编号 | MFCD00134592 |
产品性质 | 质量水平 | 100 | | 测定 | ≥97% (HPLC) | | 形式 | solid | | manufacturer/tradename | Calbiochem® | | 储存条件 | OK to freeze
protect from light | | 颜色 | white | | 溶解性 | DMSO: 100 mg/mL
ethanol: 20 mg/mL | | 运输 | ambient | | 储存温度 | −20℃ | | InChI | 1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13-,15+/m0/s1 | | InChI key | KTEXNACQROZXEV-QLIGOWBFSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H317 | | 预防措施声明 | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 | | 危险分类 | Skin Sens. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| PHL89255 | | Parthenolide | phyproof® Reference Substance | 3328.55元/20 MG; | 咨询 |
产品说明 一般描述 This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG 生化/生理作用 抑制 NF-κB 活化的抗炎剂。 法律信息 phyproof is a registered trademark of PhytoLab GmbH & Co. KG 基本信息 | 经验(实验)分子式 | C15H20O3 | | 分子量 | 248.32 | | MDL编号 | MFCD00134592 |
产品性质 | 等级 | primary reference standard | | 产品线 | phyproof® Reference Substance | | 测定 | ≥90.0% (HPLC) | | manufacturer/tradename | PhytoLab | | mp | 115-116 ℃ (lit.) | | application(s) | food and beverages | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H] | | InChI | 1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1 | | InChI key | KTEXNACQROZXEV-ZRPLFPEYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H317 | | 预防措施声明 | P280 - P302 + P352 | | 危险分类 | Skin Sens. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| 1500400 | USP | Parthenolide | United States Pharmacopeia (USP) Reference Standard | 2829.07元/25 MG; | 咨询 |
产品说明 一般描述 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia. 生化/生理作用 抑制 NF-κB 活化的抗炎剂。 分析说明 These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind. 其他说明 USP issued SDS can be found here.
Sales restrictions may apply. 基本信息 | 经验(实验)分子式 | C15H20O3 | | 分子量 | 248.32 | | MDL编号 | MFCD00134592 | | PubChem化学物质编号 | 329750677 | | NACRES | NA.24 |
产品性质 | 等级 | pharmaceutical primary standard | | manufacturer/tradename | USP | | mp | 115-116 ℃ (lit.) | | application(s) | pharmaceutical (small molecule) | | 格式 | neat | | 储存温度 | −20℃ | | SMILES string | C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H] | | InChI | 1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1 | | InChI key | KTEXNACQROZXEV-ZRPLFPEYSA-N |
安全信息 | 象形图 | | | 警示用语： | Warning | | 危险声明 | H317 | | 预防措施声明 | P280 - P302 + P352 | | 危险分类 | Skin Sens. 1 | | 储存分类代码 | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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| M02322 | Fluorochem | Parthenolide | 97% | 1254元/250mg; 3014元/1g; | 咨询 |
基本信息 | CAS Number | 20554-84-1 | | MDL Number | MFCD00134592 | | Melting Point | 115-116℃ |
安全信息 | 图形或危害标志 | | | 危险性说明 | H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
| | 防范说明 | P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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