产品说明

应用

C12-NBD ceramide is suitable for its use:

• as a substrate to measure the activity of acid, alkaline and neutral ceramidases
• in in vitro ceramidase activity assay
• in ceramide phosphoethanolamine (CPE) synthase assay to determine the K_m and V_max of sphingomyelin synthase (SMS1, SMS2, and SMSr)

生化/生理作用

Ceramide is one of the products of sphingolipid metabolism. The members of ceramide synthase family are responsible for its synthesis. Each ceramide synthesized differs in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

包装

5 mL Amber Glass Screw Cap Vial (810211C-1mg)

基本信息

产品性质

安全信息

象形图
警示用语：	Danger
危险声明	H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372
预防措施声明	P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
危险分类	Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官	Central nervous system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	does not flash
闪点(C)	does not flash

产品说明

一般描述

C12 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) ceramide is a long-chain fluorescent phospholipid. It is a natural analog of ceramide with C12 acyl chain length.

应用

C12-NBD Ceramide or N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine has been used as a substrate in ceramidase activity assay. It is also suitable for the lipid binding assays and in cell culture experiments for endothelial cells to determine the pro-apoptotic intracellular ceramide generation.

生化/生理作用

C12-7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) Ceramide is useful for measuring the alkaline and neutral ceramidase activity. It is involved in maintainingthe physical properties of ceramide required for cellular studies.

包装

5 mL Amber Glass Screw Cap Vial (810211P-1mg)

基本信息

产品性质

安全信息