| CAS: | 202475-60-3 | |||
| 分子式: | C16H15N3O3 | |||
| 分子量: | 297.31 | |||
| 中文名称: |
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| 英文名称: |
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| 用途: | JANEX-1 是一种有效的特异性 JAK3 抑制剂，Ki 为 2.3 μM，IC50 为 78 μM，JANEX-1 不抑制 JAK1 和 JAK2。 |
| 货号 | 品牌 | 产品名称 | 规格 | 包装、参考价格 | |||||||||||||||||||||||||||||||||
| W793882 | MACKLIN | 4-(4\'-羟基苯基)氨基-6, 7-二甲氧基喹唑啉 | 10mM in DMSO | 648元/1ml; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20°C | |||||||||||||||||||||||||||||||||||||
| W860951 | MACKLIN | 4-(4\'-羟基苯基)氨基-6,7-二甲氧基喹唑啉 | >98% | 198元/10mg; 405元/50mg; 761元/250mg; 2273元/1g; | 咨询 | ||||||||||||||||||||||||||||||||
储存：-20℃ 状态：浅黄色固体 折射率：light yellow solid | |||||||||||||||||||||||||||||||||||||
| 1563401 | J&K | JANEX-1 | 98%, 一种有效的特异性 JAK3 抑制剂 | 902元/5MG; 1608元/10MG; | 咨询 | ||||||||||||||||||||||||||||||||
基本信息
产品描述 JANEX-1是JAK3小分子抑制剂，选择性抑制JAK3，IC50为78 μM。它不影响JAK1或JAK2，及其他蛋白酪氨酸激酶的活性（IC50 ≥ 350 µM）。 靶点（IC50 & Targe） JAK3,Ki:2.3μM 体外研究 JANEX-1 inhibits JAK3 but not JAK1 or JAK2. The ZAP/SYK family tyrosine kinase SYK, TEC family tyrosine kinase Bruton’s tyrosine kinase (BTK), SRC family tyrosine kinase LYN, and receptor family tyrosine kinase insulin receptor kinase (IRK) are not inhibited by JANEX-1[1]. JANEX-1 suppresses IL-1β and IFN-γ-induced phosphorylation of STAT-1, STAT-3, and STAT-5 proteins. JANEX-1 has a potent inhibitory effect on cytokine-induced β-cell damage[2]. 体内研究 JANEX-1 is very well tolerated by mice and monkeys and effective plasma concentrations of JANEX-1 could be achieved at nontoxic dose levels. JANEX-1 suppresses the mitogen and antigen responses of T-cells and attenuates the severity of T-cell-dependent graft-versus-host disease in a bone marrow transplantation model[1]. 动物实验 Animal Models: Female NOD mice Formulation: DMSO in PBS Dosages: 20, 50 and 100 mg/kg/day Administration: IP (Only for Reference) 参考文献 [1] Cetkovic-Cvrlje M, et al. Clin Immunol. 2003, 106(3):213-25. [2] Lv N, et al. Exp Cell Res. 2009, 315(12):2064-71. 安全信息
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| 420101 | Sigma-Aldrich | JAK3 Inhibitor I-CAS 202475-60-3-Calbiochem | The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli | 2741.8元/5 MG; | 咨询 | ||||||||||||||||||||||||||||||||
产品说明 一般描述 A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. 包装 5 mg in Plastic ampoule 生化/生理作用 Cell permeable: yes 警告 Toxicity: Standard Handling (A) 其他说明 Tibbles, H.E., et al. 2001. J. Biol. Chem.276, 17815. 法律信息 CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany 基本信息
产品性质
安全信息
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