CAS 2010159-57-4; (s,r,s)-ahpc-peg4-nh2 hydrochloride

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CAS:

2010159-57-4

分子式:

C₃₂H₄₉N₅O₈S

分子量:

663.83

英文名称:

(s,r,s)-ahpc-peg₄-nh₂ hydrochloride

(2s,4r)-1-((s)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-n-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

用途:

(S,R,S)-AHPC-PEG4-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 个单元 PEG linker。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

S880738

MACKLIN

(S,R,S)-AHPC-PEG4-NH2

≥98%

3591元/100mg; 15390元/500mg;

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储存：2-8℃

901848

Sigma-Aldrich

(S,R,S)-AHPC-PEG₄-NH₂ hydrochloride

≥95%

9088.91元/50 MG;

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产品说明

应用

Protein degrader builiding block (S,R,S)-AHPC-PEG₄-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

基本信息

经验(实验)分子式	C₃₂H₄₉N₅O₈S · xHCl
分子量	663.83 (free base basis)
NACRES	NA.22

产品性质

测定	≥95%
形式	powder
储存温度	2-8℃
SMILES string	O=C(COCCOCCOCCOCCN)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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