CAS 19983-44-9; 6-nitro-1H-1lambda~6~-benzo[b]thiophene-1,1-dione

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规格

包装、参考价格

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S855511

MACKLIN

Stattic

95%

387元/100mg; 594元/250mg; 1260元/1g; 4039元/5g;

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储存： -20°C
状态：白色到米黄色粉末或晶体

S797148

MACKLIN

Stattic

10mM in DMSO

362元/1ml;

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储存：-20°C

Y10476

Alfa Aesar

Stattic

2686元/100mg; 4171元/250mg; 8377元/1g;

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基本信息

分子量
211.19

S7947

Sigma-Aldrich

Stattic

≥98% (HPLC), powder

2132.46元/25 MG;

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产品说明

应用

Stattic 用于抑制信号转导子和转录激活因子3(STAT3)的活性，适用各种细胞系和培养物中。
Stattic 用于研究人肺癌细胞中 Stat3 介导的细胞信号传导。⁵

包装

25 mg in glass bottle

生化/生理作用

Stattic(Stat3 三抑制化合物)改变 Stat3 的 SH2 结构域，间接抑制与磷肽结合。与其他磷酸肽类相比，它易于跨膜转运。² Stattic 诱导 ROS 形成增加，对心肌细胞线粒体功能产生负面影响，³并使鼻咽癌细胞对放化疗敏感。⁴
Stattic 是一种不可逆的 STAT3 活化抑制剂。

基本信息

经验(实验)分子式	C₈H₅NO₄S
分子量	211.19
MDL编号	MFCD00173799
PubChem化学物质编号	329824592
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: >20 mg/mL
SMILES string	[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI	1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI key	ZRRGOUHITGRLBA-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H315 - H319 - H335
预防措施声明	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

573099

Sigma-Aldrich

STAT3 Inhibitor V, Stattic-CAS 19983-44-9-Calbiochem

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

3543.57元/25 MG;

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产品说明

一般描述

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

包装

25 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
STAT3

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

其他说明

Schust, J., et al. 2006. Chem. Biol.13, 1235.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₈H₅NO₄S
分子量	211.19
MDL编号	MFCD00173799

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	pale yellow
溶解性	DMSO: 10 mg/mL ethanol: 5 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

322052

Fluorochem

6-Nitrobenzo[b]thiophene 1,1-dioxide

95%

1606元/250mg; 3190元/1g; 9592元/5g; 15994元/10g;

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基本信息

CAS Number	19983-44-9
MDL Number	MFCD00173799

安全信息

图形或危害标志
危险性说明	H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.