CAS 199798-84-0; elocalcitol

CAS:

199798-84-0

分子式:

C₂₉H₄₃FO₂

分子量:

442.7

英文名称:

elocalcitol

ro 26-9228

bxl-628

(1r,3z,5s)-3-[(2e)-2-[(3as,7as)-1-[(1s,3e)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4h-inden-4-ylidene]ethylidene]-5-fluoro-4-methylenecyclohexanol

bxl 628

用途:

BXL-628 is an analog of vitamin D3, which completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH.

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

详情

B912004

MACKLIN

BXL-628

98%

1908元/1mg;

展开

储存：-20°C，密闭，干燥

SML2395

Sigma-Aldrich

Elocalcitol

≥98% (HPLC)

1505.69元/1 MG; 4435.85元/5 MG;

展开

产品说明

生化/生理作用

Elocalcitol (BX-L628) is an analog of Vitamin D3 that acts as an agonist at vitamin D VDR receptors. It has been shown to inhibit prostate cell growth and RhoA/Rho-kinase signaling. Elocalcitol (BXL-628) downregulated the expression of active RhoA and ROCK activity induced by high glucose and was shown to have renal protective effects.
Elocalcitol is a Vitamin D receptor (VDR) agonist and is an analog of calcitriol. Elocalcitol possesses anti-inflammatory and anti- proliferative properties. It regulates cell apoptosis and cell proliferation by binding to Vitamin D receptors (VDR). It shows a therapeutic effect on people suffering from Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).

基本信息

经验(实验)分子式	C₂₉H₄₃FO₂
分子量	442.65
MDL编号	MFCD09954119

产品性质

测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D +97 to +107°, c = c=1 in methanol
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable