CAS 199666-03-0; ro 61-8048

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CAS:

199666-03-0

分子式:

C₁₇H₁₅N₃O₆S₂

分子量:

421.45

英文名称:

ro 61-8048

3,4-dimethoxy-n-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide

ro-61-8048

3,4-dimethoxy-n-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide

用途:

Ro 61-8048是一种有效的和选择性犬尿氨酸羟化酶（kynurenine hydroxylase）抑制剂，IC50为37 nM。

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货号

品牌

产品名称

规格

包装、参考价格

详情

R860922

MACKLIN

Ro 61-8048

>98%

104元/10mg; 210元/25mg; 766元/100mg; 1599元/250mg;

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储存：-20℃
状态：微黄色到黄色粉末
折射率：light yellow solid

R795343

MACKLIN

Ro 61-8048

10mM in DMSO

742元/1ml;

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储存：-20°C

SML0233

Sigma-Aldrich

Ro 61-8048

≥98% (HPLC)

1612.23元/5 MG; 4938.46元/25 MG;

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产品说明

应用

Ro 61-8048 has been used as a kynurenine 3-monooxygenase (KMO) inhibitor to study its effects on nicotinamide adenine dinucleotide (NAD⁺) concentration in hepatocytes of mice.

包装

5, 25 mg in glass bottle

生化/生理作用

Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.
Inhibition of kynurenine 3-hydroxylase by Ro 61-8048 reduces the episodes of dystonia and dyskinesias induced by decreased levels of kynurenic acid.

基本信息

经验(实验)分子式	C₁₇H₁₅N₃O₆S₂
分子量	421.45
MDL编号	MFCD11040807
PubChem化学物质编号	329825246

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	faintly yellow to yellow
溶解性	DMSO: ≥15 mg/mL
储存温度	2-8℃
SMILES string	COc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O
InChI	1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
InChI key	NDPBMCKQJOZAQX-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3

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