CAS 1986-47-6; trans-2-phenylcyclopropylamine hydrochloride

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P832943

MACKLIN

反式-2-苯基环丙胺盐酸盐

97%

39元/250mg; 149元/1g; 725元/5g;

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储存：2~8℃,干燥,密封
状态：白色到灰白色到黄色粉末或晶体

P797078

MACKLIN

反式-2-苯基环丙胺盐酸盐

10mM in DMSO

185元/1ml;

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储存：-20°C, 密封, 干燥

C13047

Alfa Aesar

trans-2-Phenylcyclopropylamine hydrochloride

97%

1245元/250mg; 2989元/1g; 12942元/5g;

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基本信息

Ref#
13047

MDL
63602

分子式
C9 H11 N . H Cl

分子量
169.66

安全信息

危险等级
6.1

包装组
III

P8511

Sigma-Aldrich

trans-2-Phenylcyclopropylamine hydrochloride

650.91元/250 MG; 1572.9元/1 G; 6268.49元/5 G;

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产品说明

包装

250 mg in glass insert
1, 5 g in poly bottle

生化/生理作用

非选择性 MAO-A/B 抑制剂。

特点和优势

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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基本信息

线性分子式	C₆H₅C₃H₄NH₂·HCl
分子量	169.65
MDL编号	MFCD00063602
PubChem化学物质编号	24278187
NACRES	NA.77

产品性质

生物来源	synthetic (organic)
质量水平	100
测定	≥97% (TLC)
形式	powder
mp	162-169 ℃ (lit.)
溶解性	ethanol: 50 mg/mL, clear to slightly hazy
储存温度	2-8℃
SMILES string	Cl.N[C@@H]1C[C@H]1c2ccccc2
InChI	1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
InChI key	ZPEFMSTTZXJOTM-OULXEKPRSA-N
Gene Information	human ... MAOA(4128), MAOB(4129)

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

P22370

Sigma-Aldrich

trans-2-Phenylcyclopropylamine hydrochloride

97%

1146.58元/1 G; 2723.01元/2.5 G;

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产品说明

包装

1, 2.5 g in glass bottle

生化/生理作用

非选择性 MAO-A/B 抑制剂。

基本信息

线性分子式	C₆H₅C₃H₄NH₂·HCl
分子量	169.65
MDL编号	MFCD00063602
PubChem化学物质编号	24898296
NACRES	NA.22

产品性质

测定	97%
旋光性	[α]/D −1 to +1.0°, c = 1 in H₂O
mp	162-169 ℃ (lit.)
储存温度	2-8℃
SMILES string	Cl.N[C@@H]1C[C@H]1c2ccccc2
InChI	1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
InChI key	ZPEFMSTTZXJOTM-OULXEKPRSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

616431

Sigma-Aldrich

Tranylcypromine, HCl-CAS 1986-47-6-Calbiochem

A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities.

1730.3元/500 MG;

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产品说明

一般描述

A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (K_i = 101.9 and 16.0 M, respectively) and LSD1/2 (K_i = 242.7 and 180.0 M, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC₅₀<2 M), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 M TCP and 10 M CHIR99061 is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).

包装

500 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Liang, Y., et al. 2009. Nat. Med.15, 1312.
Li, W., et al. 2009. Stem Cells27, 2992.
Karytinos, A., et al. 2009. J. Biol. Chem.284, 17775.
Hruschka, S., et al. 2008. Bioorg. Med. Chem.16, 7148.
Schmidt, D.M., and McCafferty, D.G. 2007. Biochemistry46, 4408.
Lee, M.G., et al. 2006. Chem. Biol.13, 563.
Yoshida, S., et al. 2004. Bioorg. Med. Chem.12, 2645.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₉H₁₁N · xHCl
分子量	133.19 (free base basis)
MDL编号	MFCD00063602

产品性质

质量水平	100
测定	≥97% (NMR)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated (hygroscopic) protect from light
颜色	white
溶解性	DMSO: 50 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m1./s1
InChI key	ZPEFMSTTZXJOTM-RJUBDTSPSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301
预防措施声明	P264 - P270 - P301 + P310 - P405 - P501
危险分类	Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3

390375

Fluorochem

(1S,2R)-2-PHENYLCYCLOPROPANAMINE HCL

95%

2112元/1g; 6182元/5g; 11132元/10g; 22286元/25g;

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基本信息

CAS Number	1986-47-6
MDL Number	MFCD00063602

安全信息

图形或危害标志
危险性说明	H301: Toxic if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. H312 + H332: Harmful in contact with skin or if inhaled
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing P264: Wash hands thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: . P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see . on this label). P330: Rinse mouth. P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to local regulations.