CAS 196868-63-0; n-(5-chloro-2-methoxyphenyl)-n′-(2-methylquinolin-4-yl)urea; pq401

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产品名称

规格

包装、参考价格

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P794726

MACKLIN

PQ 401

10mM in DMSO

696元/1ml;

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储存：-20°C

P2479

TCI

PQ401

>98.0%(HPLC)

490元/10MG; 1490元/50MG;

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基本信息

纯度/分析方法	>98.0%(HPLC)
分子式/分子量	C₁₈H₁₆ClN₃O₂ = 341.80
外观与形状(20℃)	固体
储存温度	0-10℃
储存在惰性气体下	存放于惰性气体之中
应避免的情况	空气,加热
Reaxys-RN	14012784
MDL编号	MFCD00160558

技术规格

Appearance	White to Yellow to Orange powder to crystal
Purity(HPLC)	min. 98.0 area%
Purity(with Total Nitrogen)	min. 95.0 %

物性(参考值)

熔点	190 ℃(dec.)

407248

Sigma-Aldrich

IGF-1R Inhibitor II, PQ401-CAS 196868-63-0-Calbiochem

The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

2741.8元/10 MG;

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产品说明

一般描述

A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC₅₀ = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and <1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC₅₀ = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week per i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC₅₀ = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and <1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC₅₀ = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
IGF-1R
Target IC₅₀: 12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and <1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Gable, K.L., et al. 2006. Mol. Cancer Ther.5, 1079.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₈H₁₆ClN₃O₂
分子量	341.79
MDL编号	MFCD00160558

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 10 mg/mL ethanol: 3 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

P0113

Sigma-Aldrich

PQ401

≥98% (HPLC), powder

2023.95元/10 MG;

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产品说明

应用

PQ401 has been used as:

an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
a reference inhibitor in dose-response measurements studies
an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition

包装

10 mg in glass bottle

生化/生理作用

PQ401, a diaryl urea compound that serves as an anti-glioma agent.
PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.

特点和优势

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式	C₁₈H₁₆ClN₃O₂
分子量	341.79
MDL编号	MFCD00160558
PubChem化学物质编号	24724567
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white
溶解性	DMSO: >10 mg/mL H₂O: <2 mg/mL
储存温度	2-8℃
SMILES string	COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
InChI	1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
InChI key	YBLWOZUPHDKFOT-UHFFFAOYSA-N

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

320489

Fluorochem

1-(5-Chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea

95%

19294元/1g;

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基本信息

CAS Number	196868-63-0
MDL Number	MFCD00160558