CAS 194423-15-9; pd168393

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品牌

产品名称

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包装、参考价格

P798425

MACKLIN

PD168393

10mM in DMSO

520元/1ml;

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储存：-20°C

P864281

MACKLIN

PD168393

98%

519元/10mg; 836元/50mg; 2068元/250mg; 3890元/1g;

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储存：室温
状态：白色到米黄色粉末

513033

Sigma-Aldrich

PD 168393-CAS 194423-15-9-Calbiochem

A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM).

2566.78元/1 MG;

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产品说明

一般描述

A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys⁷⁷³. Excellent antitumor agent in vivo.
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys⁷⁷³. Excellent antitumor agent in vivo.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Reversible: no
Product competes with ATP.
Target IC₅₀: 700 pM against EGFR
Primary Target
EGFR

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

其他说明

Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₇H₁₃BrN₄O
分子量	369.22
MDL编号	MFCD02179207

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 200 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

PZ0285

Sigma-Aldrich

PD168393

≥98% (HPLC)

1106.81元/5 MG; 4498.97元/25 MG;

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产品说明

应用

PD168393 has been used in the acute inhibition of ErbB4.

包装

5, 25 mg in glass bottle

生化/生理作用

PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC₅₀ value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₁₇H₁₃BrN₄O
分子量	369.22
MDL编号	MFCD02179207
PubChem化学物质编号	329823812
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 25 mg/mL, clear
创始人	Pfizer
储存温度	room temp
SMILES string	C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
InChI	1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
InChI key	HTUBKQUPEREOGA-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

527819

Fluorochem

4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

95%

6204元/10mg; 18568元/50mg;

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基本信息

CAS Number	194423-15-9
MDL Number	MFCD02179207