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CAS: 19388-87-5
分子式: C7H16N4O4S2
分子量: 284.36
英文名称: 
taurolin
taurolidine
推荐供应商
货号品牌产品名称规格包装、参考价格详情
T856885MACKLIN滔罗林98%100元/1g;   165元/5g;   768元/25g;   2276元/100g;   展开
储存:室温,干燥
状态:白色到灰白色粉末,晶体或结晶性粉末
T794771MACKLINTaurolidine10mM in DMSO185元/1ml;   展开
储存:-20°C
T3980TCITaurolidine>98.0%(T)990元/250MG;   展开

基本信息

纯度/分析方法>98.0%(T)
分子式/分子量C7H16N4O4S2 = 284.35
外观与形状(20℃)固体
储存温度0-10℃
储存在惰性气体下存放于惰性气体之中
应避免的情况光,空气,加热
Reaxys-RN550774
MDL编号MFCD00865076

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(Volumetric Analysis)min. 98.0 %
NMRconfirm to structure

物性(参考值)

熔点175 ℃

相关法规

RTECS#XI2283800
T7329Sigma-AldrichTaurolidine>97% (NMR), powder1364.72元/5 MG;   5146.64元/25 MG;   展开

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.
滔罗林是一种具有抗肿瘤活性的广谱抗生素,可以引起细胞凋亡并减少肿瘤细胞增殖。滔罗林已与肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 搭配使用以描述许多细胞凋亡相关信号蛋白的协同反应。由于无毒的滔罗林可以降低重组人肿瘤坏死因子相关凋亡诱导配体 (rhTRAIL) 的毒性和剂量,因此滔罗林与 rhTRAIL 联用的治疗方式可以为癌症治疗提供新的选择。滔罗林也被用作研究细胞凋亡和坏死的多种机理的工具。

制备说明

Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.

基本信息

经验(实验)分子式C7H16N4O4S2
分子量284.36
EC 号243-016-5
MDL编号MFCD00865076
PubChem化学物质编号329826864
NACRESNA.77

产品性质

质量水平100
测定>97% (NMR)
形式powder
储存条件protect from light
颜色 white to off-white
溶解性DMSO: >20 mg/mL
储存温度room temp
SMILES stringO=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2
InChI1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
InChI keyAJKIRUJIDFJUKJ-UHFFFAOYSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
462722FluorochemTaurolidin97%352元/5g;   1342元/25g;   4730元/100g;   展开

基本信息

CAS Number19388-87-5
MDL NumberMFCD00865076
Melting Point156℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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